CANADIAN MACROMOLECULAR CRYSTALLOGRAPHY FACILITY

Latest News and Developments

Research Highlights

REVEALING NORWALK VIRUS’ ACHILLES HEEL

The Norwalk virus belongs to a superfamily of viruses that stores their genetic code as RNA. Researchers at the University of Calgary used high-resolution data from the 08ID-1 beamline to collect information crucial for drug development.

Aug. 24, 2010

Outbreaks of Norwalk virus are notorious for causing severe dehydration due to vomiting and diarrhea. The currently untreatable bug belongs to a superfamily of viruses that stores their genetic code as RNA. Researchers at the University of Calgary used high-resolution data from the 08ID-1 beamline to determine the structure the Norwalk virus polymerase in various complexed states. The information is crucial to better understand viral replication and for drug development.

J. Biol. Chem. 283 (12), 7705-7712