CLS Mx Data Collection School

Applications now open for the 7th Annual CLS Mx Data Collection School! Application Deadline April 10

CLS Mx Data Collection School Homepage

New Pilatus detector delivered

New detector to be installed on beamline 08ID-1 this spring... click title for details!

Update on Beamline Upgrades

First phase of upgrades announced for 08ID-1, including new detector and sample changer... click title for details!

Improving antibiotics

Exploring macromolecular machines that may one day produce novel therapeutics...

Nature 529, 239-42

CMCF is an umbrella facility which operates two beamlines, 08ID-1 and 08B1-1, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.

List of Publications »

  • Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D.; Jakob, Clarissa G.; Zhu, Haizhong; Zhao, Hongyu; Wang, Ying; Ji, Zhiqin; Clark, Richard F.; Sarris, Kathy A.; Selvaraju, Sujatha; Shaw, Bailin; Algire, Mikkel A.; He, Yupeng; Richardson, Paul L.; Sweis, Ramzi F.; Sun, Chaohong; Chiang, Gary G.; Michaelides, Michael R. (2017). SAR of amino pyrrolidines as potent and novel protein-protein interact .... Bioorganic & Medicinal Chemistry Letters 27(7) , 1576-1583. 10.1016/j.bmcl.2017.02.030. [PDB: 5u69, 5u6d]
  • Abbas, Yazan M.; Laudenbach, Beatrice Theres; Martínez-Montero, Saúl; Cencic, Regina; Habjan, Matthias; Pichlmair, Andreas; Damha, Masad J.; Pelletier, Jerry; Nagar, Bhushan (2017). Structure of human IFIT1 with capped RNA reveals adaptable mRNA bindin .... Proceedings of the National Academy of Sciences 114(11) , E2106-E2115. 10.1073/pnas.1612444114. [PDB: 5udi, 5udk, 5udl]
  • Park, Jaeok; Leung, Chun Yuen; Matralis, Alexios N.; Lacbay, Cyrus M.; Tsakos, Michail; Fernandez De Troconiz, Guillermo; Berghuis, Albert M.; Tsantrizos, Youla S. (2017). Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-M .... Journal of Medicinal Chemistry 60(5) , 2119-2134. 10.1021/acs.jmedchem.6b01888. [PDB: 5juz, 5jv1]