Publications


CLS Publications Database

CMCF Peer-Reviewed Article Entries

2017 

  • Abbas, Yazan M.; Laudenbach, Beatrice Theres; Martínez-Montero, Saúl; Cencic, Regina; Habjan, Matthias; Pichlmair, Andreas; Damha, Masad J.; Pelletier, Jerry; Nagar, Bhushan (2017). Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations. Proceedings of the National Academy of Sciences 114(11) , E2106-E2115. 10.1073/pnas.1612444114. [PDB: 5udi, 5udk, 5udl]
  • Blanchard, Peter E.R.; Van Loon, Lisa L.; Reid, Joel W.; Cutler, Jeffrey N.; Rowson, John; Hughes, Kebbi A.; Brown, Caitlin B.; Mahoney, John J.; Xu, Liying; Bohan, Matthew; Demopoulos, George P. (2017). Investigating arsenic speciation in the JEB Tailings Management Facility at McClean Lake, Saskatchewan using X-ray absorption spectroscopy. Chemical Geology 466, 617-626. 10.1016/j.chemgeo.2017.07.014.
  • Cook, Jonathan D.; Sultana, Azmiri; Lee, Jeffrey E. (2017). Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proceedings of the National Academy of Sciences , 201617993. 10.1073/pnas.1617993114. [PDB: 5t96, 5t9y]
  • Copp, William; Denisov, Alexey Y.; Xie, Jingwei; Noronha, Anne M.; Liczner, Christopher; Safaee, Nozhat; Wilds, Christopher J.; Gehring, Kalle (2017). Influence of nucleotide modifications at the C2 prime position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA. Nucleic Acids Research . 10.1093/nar/gkx713. [PDB: 5vxq]
  • Crawford, Terry D.; Audia, James E.; Bellon, Steve; Burdick, Daniel J.; Bommi-Reddy, Archana; Côté, Alexandre; Cummings, Richard T.; Duplessis, Martin; Flynn, E. Megan; Hewitt, Michael; Huang, Hon-Ren; Jayaram, Hariharan; Jiang, Ying; Joshi, Shivangi; Kiefer, James R.; Murray, Jeremy; Nasveschuk, Christopher G.; Neiss, Arianne; Pardo, Eneida; Romero, F. Anthony; Sandy, Peter; Sims, Robert J.; Tang, Yong; Taylor, Alexander M.; Tsui, Vickie; Wang, Jian; Wang, Shumei; Wang, Yongyun; Xu, Zhaowu; Zawadzke, Laura; Zhu, Xiaoqin; Albrecht, Brian K.; Magnuson, Steven R.; Cochran, Andrea G. (2017). GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Medicinal Chemistry Letters 8(7) , 737-741. 10.1021/acsmedchemlett.7b00132. [PDB: 5v84]
  • Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D.; Jakob, Clarissa G.; Zhu, Haizhong; Zhao, Hongyu; Wang, Ying; Ji, Zhiqin; Clark, Richard F.; Sarris, Kathy A.; Selvaraju, Sujatha; Shaw, Bailin; Algire, Mikkel A.; He, Yupeng; Richardson, Paul L.; Sweis, Ramzi F.; Sun, Chaohong; Chiang, Gary G.; Michaelides, Michael R. (2017). SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorganic & Medicinal Chemistry Letters 27(7) , 1576-1583. 10.1016/j.bmcl.2017.02.030. [PDB: 5u69, 5u6d]
  • Eastman, Kyle J.; Parcella, Kyle; Yeung, Kap-Sun; Grant-Young, Katharine A.; Zhu, Juliang; Wang, Tao; Zhang, Zhongxing; Yin, Zhiwei; Beno, Brett R.; Sheriff, Steven; Kish, Kevin; Tredup, Jeffrey; Jardel, Adam G.; Halan, Vivek; Ghosh, Kaushik; Parker, Dawn; Mosure, Kathy; Fang, Hua; Wang, Ying-Kai; Lemm, Julie; Zhuo, Xiaoliang; Hanumegowda, Umesh; Rigat, Karen; Donoso, Maria; Tuttle, Maria; Zvyaga, Tatyana; Haarhoff, Zuzana; Meanwell, Nicholas A.; Soars, Matthew G.; Roberts, Susan B.; Kadow, John F. (2017). The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. MedChemComm . 10.1039/c6md00636a. [PDB: 5twn]
  • Eble, Johannes A.; McDougall, Matthew; Orriss, George L.; Niland, Stephan; Johanningmeier, Benjamin; Pohlentz, Gottfried; Meier, Markus; Karrasch, Simone; Estevão-Costa, Maria Inacia; Martins Lima, Augusto; Stetefeld, Jörg (2017). Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively. PLoS Biology 15(7) , e2001492. 10.1371/journal.pbio.2001492. [PDB: 5thp]
  • El-Halfawy, Omar M.; Klett, Javier; Ingram, Rebecca J.; Loutet, Slade A.; Murphy, Michael E. P.; Martín-Santamaría, Sonsoles; Valvano, Miguel A. (2017). Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. mBio 8(2) , e00225-17. 10.1128/mbio.00225-17. [PDB: 5ixg, 5ixh]
  • Fong, Desiree H.; Burk, David L.; Blanchet, Jonathan; Yan, Amy Y.; Berghuis, Albert M. (2017). Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure . 10.1016/j.str.2017.03.007. [PDB: 5igi, 5igh, 5igj, 5igp, 5igr, 5igs, 5igt, 5igu, 5igv, 5igy, 5igz, 5ih0, 5ih1, 5iwu]
  • Gorelik, Alexei; Liu, Fangyu; Illes, Katalin; Nagar, Bhushan (2017). Crystal Structure of the Human Alkaline Sphingomyelinase Provides Insights into Substrate Recognition. Journal of Biological Chemistry , jbc.M116.769273. 10.1074/jbc.m116.769273. [PDB: 5tcd, 5udy]
  • Grochulski, Pawel; Fodje, Michel; Labiuk, Shaun; Wysokinski, Tomasz W.; Belev, George; Korbas, Malgorzata; Rosendahl, Scott M. (2017). Review of Canadian Light Source facilities for biological applications. Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms . 10.1016/j.nimb.2017.01.065.
  • Guo, Shuaiqi; Stevens, Corey A.; Vance, Tyler D. R.; Olijve, Luuk L. C.; Graham, Laurie A.; Campbell, Robert L.; Yazdi, Saeed R.; Escobedo, Carlos; Bar-Dolev, Maya; Yashunsky, Victor; Braslavsky, Ido; Langelaan, David N.; Smith, Steven P.; Allingham, John S.; Voets, Ilja K.; Davies, Peter L. (2017). Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice. Science Advances 3(8) , e1701440. 10.1126/sciadv.1701440. [PDB: 5j6y, 5k8g]
  • Hewitt, Stephen Nakazawa; Dranow, David M.; Horst, Benjamin G.; Abendroth, Jan A.; Forte, Barbara; Hallyburton, Irene; Jansen, Chimed; Baragaña, Beatriz; Choi, Ryan; Rivas, Kasey L.; Hulverson, Matthew A.; Dumais, Mitchell; Edwards, Thomas E.; Lorimer, Donald D.; Fairlamb, Alan H.; Gray, David W.; Read, Kevin D.; Lehane, Adele M.; Kirk, Kiaran; Myler, Peter J.; Wernimont, Amy; Walpole, Chris; Stacy, Robin; Barrett, Lynn K.; Gilbert, Ian H.; Van Voorhis, Wesley C. (2017). Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. ACS Infectious Diseases 3(1) , 34-44. 10.1021/acsinfecdis.6b00078. [PDB: 5ifu]
  • Hu, Jinhong; Komakula, Aruna; Fraser, Marie E. (2017). Binding of hydroxycitrate to human ATP-citrate lyase. Acta Crystallographica Section D Structural Biology 73(8) , 660-671. 10.1107/s2059798317009871. [PDB: 5teq, 5tde, 5tdf, 5tdm, 5tdz, 5te1, 5tes, 5tet]
  • Huang, Xin; Chen, Hao; Shaffer, Paul L. (2017). Crystal Structures of Human GlyRα3 Bound to Ivermectin. Structure . 10.1016/j.str.2017.04.007. [PDB: 5vdi]
  • Hynes, John; Wu, Hong; Kempson, James; Duan, James J.-W.; Lu, Zhonghui; Jiang, Bin; Stachura, Sylwia; Tokarski, John S.; Sack, John S.; Khan, Javed A.; Lippy, Jonathan S.; Zhang, Rosemary F.; Pitt, Sidney; Shen, Guoxiang; Gillooly, Kate; McIntyre, Kim; Carter, Percy H.; Barrish, Joel C.; Nadler, Steven G.; Salter-Cid, Luisa M.; Fura, Aberra; Schieven, Gary L.; Pitts, William J.; Wrobleski, Stephen T. (2017). Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. Bioorganic & Medicinal Chemistry Letters . 10.1016/j.bmcl.2017.05.043. [PDB: 5vo6]
  • Jha, Vikash; Ling, Hong (2017). Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa. DNA Repair 49, 43-50. 10.1016/j.dnarep.2016.11.001. [PDB: 5t14]
  • Li, Zhijie; Fischer, Michael; Satkunarajah, Malathy; Zhou, Dongxia; Withers, Stephen G.; Rini, James M. (2017). Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1). Nature Communications 8(1) . 10.1038/s41467-017-00255-7. [PDB: 5l0r, 5l0t]
  • Li, Zhijie; Han, Kristina; Pak, John E; Satkunarajah, Malathy; Zhou, Dongxia; Rini, James M (2017). Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. Nature Chemical Biology . 10.1038/nchembio.2381. [PDB: 5kxh, 5ky0, 5ky2, 5ky3, 5ky4, 5ky5, 5ky7, 5ky8, 5ky9]
  • Lizak, Christian; Worrall, Liam J.; Baumann, Lars; Pfleiderer, Moritz M.; Volkers, Gesa; Sun, Tianjun; Sim, Lyann; Wakarchuk, Warren; Withers, Stephen G.; Strynadka, Natalie C. J. (2017). X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid. Scientific Reports 7(1) . 10.1038/s41598-017-05627-z. [PDB: 5wc6, 5wcn, 5wd7]
  • Machuqueiro, Miguel; Victor, Bruno; Switala, Jacek; Villanueva, Jacylyn; Rovira, Carme; Fita, Ignacio; Loewen, Peter C. (2017). The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine. Biochemistry 56(17) , 2271-2281. 10.1021/acs.biochem.6b01276. [PDB: 5syw, 5kq0, 5kq2, 5kq3, 5kq6, 5kqh, 5kqi, 5kqk, 5ksf, 5ksk, 5txq, 5v4o, 5v53]
  • McCallum, Matthew; Tammam, Stephanie; Khan, Ahmad; Burrows, Lori L.; Howell, P. Lynne (2017). The molecular mechanism of the type IVa pilus motors. Nature Communications 8, 15091. 10.1038/ncomms15091. [PDB: 5tsg, 5tsh]
  • McPhail, Jacob A.; Ottosen, Erik H.; Jenkins, Meredith L.; Burke, John E. (2017). The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3. Structure 25(1) , 121-131. 10.1016/j.str.2016.11.016. [PDB: 5tdq]
  • Muñoz-Escobar, Juliana; Kozlov, Guennadi; Gehring, Kalle (2017). Crystal structure of the UBR-box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding. Protein Science . 10.1002/pro.3227. [PDB: 5vmd]
  • Noach, Ilit; Ficko-Blean, Elizabeth; Pluvinage, Benjamin; Stuart, Christopher; Jenkins, Meredith L.; Brochu, Denis; Buenbrazo, Nakita; Wakarchuk, Warren; Burke, John E.; Gilbert, Michel; Boraston, Alisdair B. (2017). Recognition of protein-linked glycans as a determinant of peptidase activity. Proceedings of the National Academy of Sciences 114(5) , E679-E688. 10.1073/pnas.1615141114. [PDB: 5kdn, 5kdv, 5kdx, 5kd5, 5kd8, 5kdu, 5kdw]
  • Noguchi, Masato; Nomura, Akihiro; Murase, Ken; Doi, Satoki; Yamaguchi, Keishi; Hirata, Kazuyuki; Shiozaki, Makoto; Hirashima, Shintaro; Kotoku, Masayuki; Yamaguchi, Takayuki; Katsuda, Yoshiaki; Steensma, Ruo; Li, Xioalin; Tao, Haiyan; Tse, Bruno; Fenn, Morgan; Babine, Robert; Bradley, Erin; Crowe, Paul; Thacher, Scott; Adachi, Tsuyoshi; Kamada, Masafumi (2017). Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment. Genes to Cells 22(6) , 535-551. 10.1111/gtc.12494. [PDB: 5x8q]
  • Park, Jaeok; Leung, Chun Yuen; Matralis, Alexios N.; Lacbay, Cyrus M.; Tsakos, Michail; Fernandez De Troconiz, Guillermo; Berghuis, Albert M.; Tsantrizos, Youla S. (2017). Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. Journal of Medicinal Chemistry 60(5) , 2119-2134. 10.1021/acs.jmedchem.6b01888. [PDB: 5juz, 5jv1]
  • Park, Jaeok; Zielinski, Michal; Magder, Alexandr; Tsantrizos, Youla S.; Berghuis, Albert M. (2017). Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nature Communications 8, 14132. 10.1038/ncomms14132. [PDB: 5ja0]
  • Planken, Simon; Behenna, Douglas Carl; Nair, Sajiv K; Johnson, Theodore Otto; Nagata, Asako; Almaden, Chau; Bailey, Simon; Ballard, T. Eric; Bernier, Louise; Cheng, Hengmiao; Cho-Schultz, Sujin; Dalvie, Deepak; Deal, Judith G.; Dinh, Dac M; Edwards, Martin P.; Ferre, Rose Ann; Gajiwala, Ketan S; Hemkens, Michelle D.; Kania, Robert S; Kath, John C.; Matthews, Jean; Murray, Brion W.; Niessen, Sherry; Orr, Suvi T M; Pairish, Mason; Sach, Neal W; Shen, Hong; Shi, Manli; Solowiej, James; Tran, Khanh; Tseng, Elaine; Vicini, Paolo; Wang, Yuli; Weinrich, Scott L.; Zhou, Ru; Zientek, Michael; Liu, Longqing; Luo, Yiqin; Xin, Shuibo; Zhang, Chengyi; Lafontaine, Jennifer Anne (2017). Discovery of N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) Through Structure-Based Drug Design; A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants With Selectivity Over Wild-Type EGFR.. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.6b01894. [PDB: 5ugc]
  • Radka, Christopher D.; DeLucas, Lawrence J.; Wilson, Landon S.; Lawrenz, Matthew B.; Perry, Robert D.; Aller, Stephen G. (2017). Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal-binding sites. Acta Crystallographica Section D Structural Biology 73(7) , 557-572. 10.1107/s2059798317006349. [PDB: 5uy0, 5uy4, 5uy5, 5uya, 5uyb, 5uyc, 5uyd, 5uye, 5uyf]
  • Reid, Joel W.; Kaduk, James A.; Olson, Jeremy A. (2017). The crystal structure of Na(NH4)Mo3O10·H2O. Powder Diffraction 32(02) , 140-147. 10.1017/s0885715617000380.
  • Richter, Jeremy M.; Cheney, Daniel L.; Bates, J. Alex; Wei, Anzhi; Luettgen, Joseph M.; Rendina, Alan R.; Harper, Timothy M.; Narayanan, Rangaraj; Wong, Pancras C.; Seiffert, Dietmar; Wexler, Ruth R.; Priestley, E. Scott (2017). Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Medicinal Chemistry Letters 8(1) , 67-72. 10.1021/acsmedchemlett.6b00375. [PDB: 5tqe]
  • Sakurada, Isao; Endo, Toshiya; Hikita, Katsuyoshi; Hirabayashi, Tomokazu; Hosaka, Yoshitaka; Kato, Yutaka; Maeda, Yoshitaka; Matsumoto, Shigeki; Mizuno, Takashi; Nagasue, Hiroshi; Nishimura, Teruyuki; Shimada, Shunsuke; Shinozaki, Mikihiko; Taguchi, Keiko; Takeuchi, Katsutoshi; Yokoyama, Tooru; Hruza, Alan; Reichert, Paul; Zhang, Ting; Wood, Harold B.; Nakao, Kazunari; Furusako, Shoji (2017). Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors. Bioorganic & Medicinal Chemistry Letters . 10.1016/j.bmcl.2017.03.002. [PDB: 5tnt]
  • Tarry, Michael J.; Haque, Asfarul S.; Bui, Khanh Huy; Schmeing, T. Martin (2017). X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture. Structure 25(5) , 783-793.e4. 10.1016/j.str.2017.03.014. [PDB: 5u89]
  • Ulaganathan, ThirumalaiSelvi; Boniecki, Michal T.; Foran, Elizabeth; Buravenkov, Vitaliy; Mizrachi, Naama; Banin, Ehud; Helbert, William; Cygler, Miroslaw (2017). New Ulvan-Degrading Polysaccharide Lyase Family: Structure and Catalytic Mechanism Suggests Convergent Evolution of Active Site Architecture. ACS Chemical Biology . 10.1021/acschembio.7b00126. [PDB: 5uam, 5uas]
  • Vadlamani, Grishma; Stubbs, Keith A.; Désiré, Jérôme; Blériot, Yves; Vocadlo, David J.; Mark, Brian L. (2017). Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Protein Science . 10.1002/pro.3166. [PDB: 5utr]
  • Wahba, Haytham M.; Stevenson, Michael J.; Mansour, Ahmed; Sygusch, Jurgen; Wilcox, Dean E.; Omichinski, James G. (2017). Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon–Metal Bond Cleavage. Journal of the American Chemical Society 139(2) , 910-921. 10.1021/jacs.6b11327. [PDB: 5u79, 5u7b, 5u7c, 5u82, 5u83]
  • Wilsbacher, Julie L.; Cheng, Min; Cheng, Dong; Trammell, Samuel A.J.; Shi, Yan; Guo, Jun; Koeniger, Stormy L.; Kovar, Peter J.; He, Yupeng; Selvaraju, Sujatha; Heyman, H. Robin; Sorensen, Bryan K.; Clark, Richard F.; Hansen, T. Matthew; Longenecker, Kenton L.; Raich, Diana; Korepanova, Alla V.; Cepa, Steven; Towne, Danli L.; Abraham, Vivek C.; Tang, Hua; Richardson, Paul L.; McLoughlin, Shaun M.; Badagnani, Ilaria; Curtin, Michael L.; Michaelides, Michael R.; Maag, David; Buchanan, F. Gregory; Chiang, Gary G.; Gao, Wenqing; Rosenberg, Saul H.; Brenner, Charles; Tse, Chris (2017). Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics 16(7) , 1236-1245. 10.1158/1535-7163.mct-16-0819. [PDB: 5u2m]
  • Yeung, Kap-Sun; Beno, Brett R.; Parcella, Kyle; Bender, John A.; Grant-Young, Katherine A.; Nickel, Andrew; Gunaga, Prashantha; Anjanappa, Prakash; Bora, Rajesh Onkardas; Selvakumar, Kumaravel; Rigat, Karen; Wang, Ying-Kai; Liu, Mengping; Lemm, Julie; Mosure, Kathy; Sheriff, Steven; Wan, Changhong; Witmer, Mark; Kish, Kevin; Hanumegowda, Umesh; Zhuo, Xiaoliang; Shu, Yue-Zhong; Parker, Dawn; Haskell, Roy; Ng, Alicia; Gao, Qi; Colston, Elizabeth; Raybon, Joseph; Grasela, Dennis M.; Santone, Kenneth; Gao, Min; Meanwell, Nicholas A.; Sinz, Michael; Soars, Matthew G.; Knipe, Jay O.; Roberts, Susan B.; Kadow, John F. (2017). Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.7b00328. [PDB: 5pzp]
  • Zhang, Wei; Bailey-Elkin, Ben A.; Knaap, Robert C. M.; Khare, Baldeep; Dalebout, Tim J.; Johnson, Garrett G.; van Kasteren, Puck B.; McLeish, Nigel J.; Gu, Jun; He, Wenguang; Kikkert, Marjolein; Mark, Brian L.; Sidhu, Sachdev S. (2017). Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PLoS Pathogens 13(5) , e1006372. 10.1371/journal.ppat.1006372. [PDB: 5v5g]
  • Zhao, Jianhua; Beyrakhova, Ksenia; Liu, Yao; Alvarez, Claudia P.; Bueler, Stephanie A.; Xu, Li; Xu, Caishuang; Boniecki, Michal T.; Kanelis, Voula; Luo, Zhao-Qing; Cygler, Miroslaw; Rubinstein, John L. (2017). Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathogens 13(6) , e1006394. 10.1371/journal.ppat.1006394. [PDB: 5ufk]

2016 

  • Almawi, Ahmad W.; Matthews, Lindsay A.; Larasati, ; Myrox, Polina; Boulton, Stephen; Lai, Christine; Moraes, Trevor; Melacini, Giuseppe; Ghirlando, Rodolfo; Duncker, Bernard P.; Guarné, Alba (2016). ‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7. Scientific Reports 6, 34237. 10.1038/srep34237. [PDB: 5t2s]
  • Argyropoulos, Panos; Bergeret, Fabien; Pardin, Christophe; Reimer, Janice M.; Pinto, Atahualpa; Boddy, Christopher N.; Schmeing, T. Martin (2016). Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. Biochimica et Biophysica Acta (BBA) - General Subjects 1860(3) , 486-497. 10.1016/j.bbagen.2015.11.007. [PDB: 5d3k]
  • Aydin, Halil; Sultana, Azmiri; Li, Sheng; Thavalingam, Annoj; Lee, Jeffrey E. (2016). Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. Nature 534(7608) , 562-565. 10.1038/nature18595. [PDB: 5f4v, 5f4e, 5f4t]
  • Blake, James F.; Burkard, Michael; Chan, Jocelyn; Chen, Huifen; Chou, Kang-Jye; Diaz, Dolores; Dudley, Danette A.; Gaudino, John J.; Gould, Stephen E.; Grina, Jonas; Hunsaker, Thomas; Liu, Lichuan; Martinson, Matthew; Moreno, David; Mueller, Lars; Orr, Christine; Pacheco, Patricia; Qin, Ann; Rasor, Kevin; Ren, Li; Robarge, Kirk; Shahidi-Latham, Sheerin; Stults, Jeffrey; Sullivan, Francis; Wang, Weiru; Yin, Jianping; Zhou, Aihe; Belvin, Marcia; Merchant, Mark; Moffat, John; Schwarz, Jacob B. (2016). Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. Journal of Medicinal Chemistry 59(12) , 5650-5660. 10.1021/acs.jmedchem.6b00389. [PDB: 5k4i]
  • Bloudoff, Kristjan; Alonzo, Diego A.; Schmeing, T. Martin (2016). Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases. Cell Chemical Biology 23(3) , 331-339. 10.1016/j.chembiol.2016.02.012. [PDB: 5dua, 5du9]
  • Bloudoff, Kristjan; Fage, Christopher D.; Marahiel, Mohamed A.; Schmeing, T. Martin (2016). Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis. Proceedings of the National Academy of Sciences 114(1) , 95-100. 10.1073/pnas.1614191114. [PDB: 5t3e]
  • Caldwell, Shane J.; Huang, Yue; Berghuis, Albert M. (2016). Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia. Structure . 10.1016/j.str.2016.04.002. [PDB: 5iqh, 5byl, 5iqb, 5iqc, 5iqg, 5iqa, 5iqe, 5iqd]
  • Chaudet, Marcia; Rose, David (2016). Alternative starch utilization system from the human gut bacterium Bacteroides thetaiotaomicron.. Biochemistry and Cell Biology . 10.1139/bcb-2016-0002. [PDB: 5f7c, 5djw]
  • Chiu, Hsien-Chieh; Lu, Xia; Zhou, Jigang; Gu, Lin; Reid, Joel; Gauvin, Raynald; Zaghib, Karim; Demopoulos, George P. (2016). Capacity Fade Mechanism of Li4 Ti5 O12 Nanosheet Anode. Advanced Energy Materials , 1601825. 10.1002/aenm.201601825.
  • Crawford, Terry D.; Romero, F. Anthony; Lai, Kwong Wah; Tsui, Vickie; Taylor, Alexander M.; de Leon Boenig, Gladys; Noland, Cameron L.; Murray, Jeremy; Ly, Justin; Choo, Edna F.; Hunsaker, Thomas L.; Chan, Emily W.; Merchant, Mark; Kharbanda, Samir; Gascoigne, Karen E.; Kaufman, Susan; Beresini, Maureen H.; Liao, Jiangpeng; Liu, Wenfeng; Chen, Kevin X.; Chen, Zhongguo; Conery, Andrew R.; Côté, Alexandre; Jayaram, Hariharan; Jiang, Ying; Kiefer, James R.; Kleinheinz, Tracy; Li, Yingjie; Maher, Jonathan; Pardo, Eneida; Poy, Florence; Spillane, Kerry L.; Wang, Fei; Wang, Jian; Wei, Xiaocang; Xu, Zhaowu; Xu, Zhongya; Yen, Ivana; Zawadzke, Laura; Zhu, Xiaoyu; Bellon, Steven; Cummings, Richard; Cochran, Andrea G.; Albrecht, Brian K.; Magnuson, Steven (2016). Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry 59(23) , 10549-10563. 10.1021/acs.jmedchem.6b01022. [PDB: 5ktw]
  • Crawford, Terry D.; Tsui, Vickie; Flynn, E. Megan; Wang, Shumei; Taylor, Alexander M.; Côté, Alexandre; Audia, James E.; Beresini, Maureen H.; Burdick, Daniel J.; Cummings, Richard; Dakin, Les A.; Duplessis, Martin; Good, Andrew C.; Hewitt, Michael C.; Huang, Hon-Ren; Jayaram, Hariharan; Kiefer, James R.; Jiang, Ying; Murray, Jeremy; Nasveschuk, Christopher G.; Pardo, Eneida; Poy, Florence; Romero, F. Anthony; Tang, Yong; Wang, Jian; Xu, Zhaowu; Zawadzke, Laura E.; Zhu, Xiaoyu; Albrecht, Brian K.; Magnuson, Steven R.; Bellon, Steve; Cochran, Andrea G. (2016). Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. Journal of Medicinal Chemistry 59(11) , 5391-5402. 10.1021/acs.jmedchem.6b00264. [PDB: 5i29]
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  • Tebben, Andrew J.; Ruzanov, Maxim; Gao, Mian; Xie, Dianlin; Kiefer, Susan E.; Yan, Chunhong; Newitt, John A.; Zhang, Liping; Kim, Kyoung; Lu, Hao; Kopcho, Lisa M.; Sheriff, Steven (2016). Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity. Acta Crystallographica Section D Structural Biology 72(5) , 658-674. 10.1107/s2059798316003624. [PDB: 5e8u]
  • Torres, Miguel A.; Hoffarth, Elesha; Eugenio, Luiz; Savtchouk, Julia; Chen, Xue; Morris, Jeremy; Facchini, Peter J.; Ng, Kenneth K.S. (2016). Structural and Functional Studies of Pavine N-Methyltransferase fromThalictrum flavumReveal Novel Insights into Substrate Recognition and Catalytic Mechanism. Journal of Biological Chemistry , jbc.M116.747261. 10.1074/jbc.m116.747261. [PDB: 5kn4, 5kpc]
  • Ulaganathan, ThirumalaiSelvi; Shi, Rong; Yao, Deqiang; Gu, Ruo-Xu; Garron, Marie-Line; Cherney, Maia; Tieleman, D. Peter; Sterner, Eric; Li, Guoyun; Li, Lingyun; Linhardt, Robert J.; Cygler, Miroslaw (2016). Conformational Flexibility of PL12 family Heparinases: Structure and Substrate Specificity of Heparinase III fromBacteroides thetaiotaomicron(BT4657). Glycobiology , cww096. 10.1093/glycob/cww096. [PDB: 5jmd]
  • Vashchenko, Ganna; Das, Samir; Moon, Kyung-Mee; Rogalski, Jason C.; Taves, Matthew D.; Soma, Kiran K.; Van Petegem, Filip; Foster, Leonard J.; Hammond, Geoffrey L. (2016). Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein. Journal of Biological Chemistry 291(21) , 11300-11312. 10.1074/jbc.m116.714378. [PDB: 5hgc]
  • Vinogradova, Maia; Gehling, Victor S; Gustafson, Amy; Arora, Shilpi; Tindell, Charles A; Wilson, Catherine; Williamson, Kaylyn E; Guler, Gulfem D; Gangurde, Pranoti; Manieri, Wanda; Busby, Jennifer; Flynn, E Megan; Lan, Fei; Kim, Hyo-jin; Odate, Shobu; Cochran, Andrea G; Liu, Yichin; Wongchenko, Matthew; Yang, Yibin; Cheung, Tommy K; Maile, Tobias M; Lau, Ted; Costa, Michael; Hegde, Ganapati V; Jackson, Erica; Pitti, Robert; Arnott, David; Bailey, Christopher; Bellon, Steve; Cummings, Richard T; Albrecht, Brian K; Harmange, Jean-Christophe; Kiefer, James R; Trojer, Patrick; Classon, Marie (2016). An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nature Chemical Biology 12(7) , 531-538. 10.1038/nchembio.2085. [PDB: 5ceh]
  • Wahba, Haytham; Lecoq, Lauriane; Stevenson, Michael J; Mansour, Ahmed; Cappadocia, Laurent; Lafrance-Vanasse, Julien; Wilkinson, Kevin J; Sygusch, Jurgen; Wilcox, Dean E.; Omichinski, James G (2016). Structural and biochemical characterization of a copper-binding mutant of the organomercurial lyase MerB: Insight into the key role of the active site aspartic acid in both Hg-carbon bond cleavage and metal-binding specificity.. Biochemistry . 10.1021/acs.biochem.5b01298. [PDB: 5c17]
  • Watterson, Scott H.; De Lucca, George V.; Shi, Qing; Langevine, Charles M.; Liu, Qingjie; Batt, Douglas G.; Beaudoin Bertrand, Myra; Gong, Hua; Dai, Jun; Yip, Shiuhang; Li, Peng; Sun, Dawn; Wu, Dauh-Rurng; Wang, Chunlei; Zhang, Yingru; Traeger, Sarah C.; Pattoli, Mark A.; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T.; Vickery, Rodney; Discenza, Lorell N.; D’Arienzo, Celia J.; Zhang, Yifan; Heimrich, Elizabeth; Gillooly, Kathleen M.; Taylor, Tracy L.; Pulicicchio, Claudine; McIntyre, Kim W.; Galella, Michael A.; Tebben, Andy J.; Muckelbauer, Jodi K.; Chang, ChiehYing; Rampulla, Richard; Mathur, Arvind; Salter-Cid, Luisa; Barrish, Joel C.; Carter, Percy H.; Fura, Aberra; Burke, James R.; Tino, Joseph A. (2016). Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. Journal of Medicinal Chemistry 59(19) , 9173-9200. 10.1021/acs.jmedchem.6b01088. [PDB: 5t18]
  • Wheatley, Robert W.; Ng, Kenneth K.S.; Kapoor, Manju (2016). Fungal cobalamin-independent methionine synthase: Insights from the model organism, Neurospora crassa. Archives of Biochemistry and Biophysics 590, 125-137. 10.1016/j.abb.2015.11.037. [PDB: 4zty]
  • Wu, Wen-Lian; Hao, Jinsong; Domalski, Martin; Burnett, Duane A.; Pissarnitski, Dmitri; Zhao, Zhiqiang; Stamford, Andrew; Scapin, Giovanna; Gao, Ying-Duo; Soriano, Aileen; Kelly, Terri M.; Yao, Zuliang; Powles, Mary Ann; Chen, Shiying; Mei, Hong; Hwa, Joyce (2016). Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Medicinal Chemistry Letters 7(5) , 498-501. 10.1021/acsmedchemlett.6b00027. [PDB: 5i7u]
  • Wu, Yong-Jin; Guernon, Jason; Shi, Jianliang; Marcin, Lawrence; Higgins, Mendi; Rajamani, Ramkumar; Muckelbauer, Jodi; Lewis, Hal; Chang, ChiehYing; Camac, Dan; Toyn, Jeremy H.; Ahlijanian, Michael K.; Albright, Charles F.; Macor, John E.; Thompson, Lorin A. (2016). Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.6b01012. [PDB: 5kr8]
  • Yamniuk, Aaron P.; Suri, Anish; Krystek, Stanley R.; Tamura, James; Ramamurthy, Vidhyashankar; Kuhn, Robert; Carroll, Karen; Fleener, Catherine; Ryseck, Rolf; Cheng, Lin; An, Yongmi; Drew, Philip; Grant, Steven; Suchard, Suzanne J.; Nadler, Steven G.; Bryson, James W.; Sheriff, Steven (2016). Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope. Journal of Molecular Biology 428(14) , 2860-2879. 10.1016/j.jmb.2016.05.014. [PDB: 5dmi, 5dmj]
  • Zhao, Jianbao; Reid, Joel; Iida, Tsutomu; Takarabe, Kenichi; Wu, Min; Tse, John S. (2016). Valence charge density of multi-doped Mg2Si thermoelectric materials from maximum entropy method analysis. Journal of Alloys and Compounds 681, 66-74. 10.1016/j.jallcom.2016.04.206.
  • Zhou, Yan-Feng; Metcalf, Matthew C.; Garman, Scott C.; Edmunds, Tim; Qiu, Huawei; Wei, Ronnie R. (2016). Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease. Nature Communications 7, 13082. 10.1038/ncomms13082. [PDB: 5i8r]

2015 

  • Adamiak, Paul; Calmettes, Charles; Moraes, Trevor F.; Schryvers, Anthony B. (2015). Patterns of structural and sequence variation within isotype lineages of the Neisseria meningitidis transferrin receptor system. MicrobiologyOpen 4(3) , 491-504. 10.1002/mbo3.254. [PDB: 4qq1]
  • Bacik, John-Paul; Klesmith, Justin R.; Whitehead, Timothy A.; Jarboe, Laura R.; Unkefer, Clifford J.; Mark, Brian L.; Michalczyk, Ryszard (2015). Producing Glucose 6-Phosphate from Cellulosic Biomass. Journal of Biological Chemistry 290(44) , 26638-26648. 10.1074/jbc.m115.674614. [PDB: 5bsb, 4zlu, 4zfv, 4yh5]
  • Baker, Perrin; Whitfield, Gregory B.; Hill, Preston J.; Little, Dustin J.; Pestrak, Matthew J.; Robinson, Howard; Wozniak, Daniel J.; Howell, P. Lynne (2015). Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals that its Levels are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation.. Journal of Biological Chemistry , jbc.M115.674929. 10.1074/jbc.m115.674929. [PDB: 5bxa]
  • Bamford, Natalie C.; Snarr, Brendan D.; Gravelat, Fabrice N.; Little, Dustin J.; Lee, Mark J.; Zacharias, Caitlin A.; Chabot, Josée C.; Geller, Alexander M.; Baptista, Stefanie D.; Baker, Perrin; Robinson, Howard; Howell, P. Lynne; Sheppard, Donald C. (2015). Sph3 is a glycoside hydrolase required for the biosynthesis of galactosaminogalactan in Aspergillus fumigatus. Journal of Biological Chemistry , jbc.M115.679050. 10.1074/jbc.m115.679050. [PDB: 5d6t]
  • Baral, Pravas Kumar; Swayampakula, Mridula; Aguzzi, Adriano; James, Michael N.G. (2015). X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. Journal of Structural Biology 192(1) , 37-47. 10.1016/j.jsb.2015.08.014. [PDB: 4yx2]
  • Bergeron, Julien R. C.; Fernández, Lucia; Wasney, Gregory A.; Vuckovic, Marija; Reffuveille, Fany; Hancock, Robert E. W.; Strynadka, Natalie C. J. (2015). The Structure of a T3SS Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing. Journal of Biological Chemistry , jbc.M115.684423. 10.1074/jbc.m115.684423. [PDB: 5cuk, 5cul]
  • Blackler, Ryan J.; Evans, Dylan W.; Smith, David F.; Cummings, Richard D.; Brooks, Cory L.; Braulke, Thomas; Liu, Xinyu; Evans, Stephen V.; Müller-Loennies, Sven (2015). Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide specific binding pocket that distinguishes N -glycan phosphorylation in a branch specific manner. Glycobiology , cwv093. 10.1093/glycob/cwv093. [PDB: 4rzc]
  • Calmettes, Charles; Ing, Christopher; Buckwalter, Carolyn M.; El Bakkouri, Majida; Chieh-Lin Lai, Christine; Pogoutse, Anastassia; Gray-Owen, Scott D.; Pomès, Régis; Moraes, Trevor F. (2015). The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD. Nature Communications 6, 7996. 10.1038/ncomms8996. [PDB: 4rvw, 4rdr]
  • Clifton, Matthew C.; Dranow, David M.; Leed, Alison; Fulroth, Ben; Fairman, James W.; Abendroth, Jan; Atkins, Kateri A.; Wallace, Ellen; Fan, Dazhong; Xu, Guoping; Ni, Z. J.; Daniels, Doug; Van Drie, John; Wei, Guo; Burgin, Alex B.; Golub, Todd R.; Hubbard, Brian K.; Serrano-Wu, Michael H. (2015). A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. PLoS ONE 10(4) , e0125010. 10.1371/journal.pone.0125010. [PDB: 4wmu]
  • Concha, N. O.; Smallwood, A.; Bonnette, W.; Totoritis, R.; Zhang, G.; Federowicz, K.; Yang, J.; Qi, H.; Chen, S.; Campobasso, N.; Choudhry, A. E.; Shuster, L. E.; Evans, K. A.; Ralph, J.; Sweitzer, S.; Heerding, D. A.; Buser, C. A.; Su, D.-S.; DeYoung, M. P. (2015). Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1  Endoribonuclease Activity. Molecular Pharmacology 88(6) , 1011-1023. 10.1124/mol.115.100917. [PDB: 4yzd]
  • Cook, Jonathan D.; Soto-Montoya, Hazel; Korpela, Markus K.; Lee, Jeffrey E. (2015). Electrostatic Architecture of the Infectious Salmon Anemia Virus (ISAV) Core Fusion Protein Illustrates a Carboxyl-Carboxylate pH-Sensor. Journal of Biological Chemistry , jbc.M115.644781. 10.1074/jbc.m115.644781. [PDB: 4xyp]
  • Cuskin, Fiona; Lowe, Elisabeth C.; Temple, Max J.; Zhu, Yanping; Cameron, Elizabeth A.; Pudlo, Nicholas A.; Porter, Nathan T.; Urs, Karthik; Thompson, Andrew J.; Cartmell, Alan; Rogowski, Artur; Hamilton, Brian S.; Chen, Rui; Tolbert, Thomas J.; Piens, Kathleen; Bracke, Debby; Vervecken, Wouter; Hakki, Zalihe; Speciale, Gaetano; Munōz-Munōz, Jose L.; Day, Andrew; Peña, Maria J.; McLean, Richard; Suits, Michael D.; Boraston, Alisdair B.; Atherly, Todd; Ziemer, Cherie J.; Williams, Spencer J.; Davies, Gideon J.; Abbott, D. Wade; Martens, Eric C.; Gilbert, Harry J. (2015). Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. Nature 517(7533) , 165-169. 10.1038/nature13995. [PDB: 4c1r, 4c1s]
  • D’Costa, Vanessa M.; Braun, Virginie; Landekic, Marija; Shi, Rong; Proteau, Ariane; McDonald, Laura; Cygler, Miroslaw; Grinstein, Sergio; Brumell, John H. (2015). Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7. Cell Reports 12(9) , 1508-1518. 10.1016/j.celrep.2015.07.063. [PDB: 5cq9]
  • Farha, Maya A.; Czarny, Tomasz L.; Myers, Cullen L.; Worrall, Liam J.; French, Shawn; Conrady, Deborah G.; Wang, Yang; Oldfield, Eric; Strynadka, Natalie C. J.; Brown, Eric D. (2015). Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proceedings of the National Academy of Sciences 112(35) , 11048-11053. 10.1073/pnas.1511751112. [PDB: 5cqj, 5cqb]
  • Galka, Marek M.; Rajagopalan, Nandhakishore; Buhrow, Leann M.; Nelson, Ken M.; Switala, Jacek; Cutler, Adrian J.; Palmer, David R. J.; Loewen, Peter C.; Abrams, Suzanne R.; Loewen, Michele C. (2015). Identification of Interactions between Abscisic Acid and Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase. PLoS ONE 10(7) , e0133033. 10.1371/journal.pone.0133033.
  • Grebien, Florian; Vedadi, Masoud; Getlik, Matthäus; Giambruno, Roberto; Grover, Amit; Avellino, Roberto; Skucha, Anna; Vittori, Sarah; Kuznetsova, Ekaterina; Smil, David; Barsyte-Lovejoy, Dalia; Li, Fengling; Poda, Gennadiy; Schapira, Matthieu; Wu, Hong; Dong, Aiping; Senisterra, Guillermo; Stukalov, Alexey; Huber, Kilian V M; Schönegger, Andreas; Marcellus, Richard; Bilban, Martin; Bock, Christoph; Brown, Peter J; Zuber, Johannes; Bennett, Keiryn L; Al-awar, Rima; Delwel, Ruud; Nerlov, Claus; Arrowsmith, Cheryl H; Superti-Furga, Giulio (2015). Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology 11(8) , 571-578. 10.1038/nchembio.1859. [PDB: 4ql1]
  • Gregg, Katie J.; Suits, Michael D.L.; Deng, Lehua; Vocadlo, David J.; Boraston, Alisdair B. (2015). Structural analysis of a family 101 glycoside hydrolase in complex with carbohydrates reveals insights into its mechanism. Journal of Biological Chemistry , jbc.M115.680470. 10.1074/jbc.m115.680470.
  • Gritzalis, Dimitrios; Park, Jaeok; Chiu, Wei; Cho, Hyungjun; Lin, Yih-Shyan; De Schutter, Joris W.; Lacbay, Cyrus M.; Zielinski, Michal; Berghuis, Albert M.; Tsantrizos, Youla S. (2015). Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & Medicinal Chemistry Letters 25(5) , 1117-1123. 10.1016/j.bmcl.2014.12.089. [PDB: 4qxs]
  • Haji-Ghassemi, Omid; Müller-Loennies, Sven; Rodriguez, Teresa; Brade, Lore; Kosma, Paul; Brade, Helmut; Evans, Stephen V. (2015). Structural Basis for Antibody Recognition of Lipid A: Insights to Polyspecificity Toward Single Stranded DNA. Journal of Biological Chemistry , jbc.M115.657874. 10.1074/jbc.m115.657874. [PDB: 4z95, 4odv, 4odw, 4odt, 4odu, 4z8f]
  • Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan; Chan, Emily; Chen, Yuan; Clausen, Saundra; Dominguez-Fernandez, Belen; Eigenbrot, Charles; Elliott, Richard; Hanan, Emily J.; Jackson, Philip; Knight, Jamie; La, Hank; Lainchbury, Michael; Malek, Shiva; Mann, Sam; Merchant, Mark; Mortara, Kyle; Purkey, Hans; Schaefer, Gabriele; Schmidt, Stephen; Seward, Eileen; Sideris, Steve; Shao, Lily; Wang, Shumei; Yeap, Kuen; Yen, Ivana; Yu, Christine; Heffron, Timothy P. (2015). Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.5b01412. [PDB: 5cal, 5cao, 5cap]
  • Helliwell, John R.; Mitchell, Edward P. (2015). Synchrotron radiation macromolecular crystallography: science and spin-offs. IUCrJ 2(2) , 283-291. 10.1107/s205225251402795x.
  • Hodge, Curtis D.; Edwards, Ross A.; Markin, Craig J.; McDonald, Darin; Pulvino, Mary; Huen, Michael S. Y.; Zhao, Jiyong; Spyracopoulos, Leo; Hendzel, Michael J.; Glover, J. N. Mark (2015). Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chemical Biology 10(7) , 1718-1728. 10.1021/acschembio.5b00222. [PDB: 4onm, 4onn]
  • Huang, Ji; Malhi, Manpreet; Deneke, Jan; Fraser, Marie Elizabeth (2015). Structure of GTP-specific succinyl-CoA synthetase in complex with CoA. Acta Crystallographica Section F Structural Biology Communications 71(8) , 1067-1071. 10.1107/s2053230x15011188. [PDB: 4xx0]
  • Johnson, Troy A.; Mcleod, Matthew J; Holyoak, Todd (2015). Utilization of substrate intrinsic binding energy for conformational change and catalytic function in phosphoenolpyruvate carboxykinase.. Biochemistry . 10.1021/acs.biochem.5b01215. [PDB: 5fh0, 5fh2, 5fh1]
  • Kim, Jitae; Kimber, Matthew S.; Nishimura, Kenji; Friso, Giulia; Schultz, Lance; Ponnala, Lalit; van Wijk, Klaas J. (2015). Structures, Functions, and Interactions of ClpT1 and ClpT2 in the Clp Protease System of Arabidopsis Chloroplasts. The Plant Cell , tpc.15.00106. 10.1105/tpc.15.00106. [PDB: 4y0b]
  • King, Dustin T.; King, Andrew M.; Lal, Sarah M.; Wright, Gerard D.; Strynadka, Natalie C. J. (2015). Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition. ACS Infectious Diseases , 150211110915002. 10.1021/acsinfecdis.5b00007. [PDB: 4s2p, 4s2k, 4s2n, 4s2i, 4s2o, 4s2j]
  • Kwan, David H.; Constantinescu, Iren; Chapanian, Rafi; Higgins, Melanie A.; Kötzler, Miriam P; Samain, Eric; Boraston, Alisdair B.; Kizhakkedathu, Jayachandran N.; Withers, Stephen G. (2015). Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society , 150424072906003. 10.1021/ja5116088. [PDB: 4d6g, 4d6d, 4d6e, 4d6c]
  • Lang, Shenhui; Cressatti, Marisa; Mendoza, Kris E.; Coumoundouros, Chelsea N.; Plater, Samantha M.; Culham, Doreen E.; Kimber, Matthew S.; Wood, Janet M. (2015). YehZYXW of Escherichia coli Is a Low-Affinity, Non-Osmoregulatory Betaine-Specific ABC Transporter. Biochemistry 54(37) , 5735-5747. 10.1021/acs.biochem.5b00274. [PDB: 4wep]
  • Little, Dustin J.; Milek, Sonja; Bamford, Natalie C.; Ganguly, Tridib; DiFrancesco, Benjamin R.; Nitz, Mark; Deora, Rajendar; Howell, P. Lynne (2015). BpsB is a Poly-β-1,6- N -acetyl-D-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica. Journal of Biological Chemistry , jbc.M115.672469. 10.1074/jbc.m115.672469. [PDB: 5bu6]
  • Liu, Yiyi; Khalili Najafabadi, Bahareh; Azizpoor Fard, Mahmood; Corrigan, John F. (2015). A Functionalized Ag 2 S Molecular Architecture: Facile Assembly of the Atomically Precise Ferrocene-Decorated Nanocluster [Ag 74 S 19 (dppp) 6 (fc(C{O}OCH 2 CH 2 S) 2 ) 18 ]. Angewandte Chemie , n/a-n/a. 10.1002/ange.201411944.
  • Loewen, Peter C.; Villanueva, Jacylyn; Switala, Jacek; Donald, Lynda J.; Ivancich, Anabella (2015). Unprecedented access of phenolic substrates to the heme active site of a catalase: Substrate binding and peroxidase-like reactivity of Bacillus pumilus catalase monitored by X-ray crystallography and EPR spectroscopy. Proteins Structure Function and Bioinformatics , n/a-n/a. 10.1002/prot.24777. [PDB: 4qol, 4qoq, 4qop, 4qon, 4qoo, 4qom]
  • Lugo, Miguel R.; Merrill, A. Rod (2015). Pocket analysis of the full-length cholix toxin. An assessment of the structure–dynamics of the apo catalytic domain. Journal of Biomolecular Structure and Dynamics 33(11) , 2452-2468. 10.1080/07391102.2014.1000972.
  • Lugo, Miguel; Merrill, A. (2015). The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family. Toxins 7(8) , 2757-2772. 10.3390/toxins7082757.
  • Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David; Dong, Ping; Dornan, Laura M.; Duron, Sergio; Epler, Jennifer; Gazzard, Lewis; Heise, Christopher E.; Hoeflich, Klaus P.; Jakubiak, Diana; La, Hank; Lee, Wendy; Lin, Baiwei; Lyssikatos, Joseph P.; Maksimoska, Jasna; Marmorstein, Ronen; Murray, Lesley J.; O’Brien, Thomas; Oh, Angela; Ramaswamy, Sreemathy; Wang, Weiru; Zhao, Xianrui; Zhong, Yu; Blackwood, Elizabeth; Rudolph, Joachim (2015). Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar Moiety. ACS Medicinal Chemistry Letters . 10.1021/acsmedchemlett.5b00398.
  • Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David; Dong, Ping; Dornan, Laura M.; Duron, Sergio; Epler, Jennifer; Gazzard, Lewis; Heise, Christopher E.; Hoeflich, Klaus P.; Jakubiak, Diana; La, Hank; Lee, Wendy; Lin, Baiwei; Lyssikatos, Joseph P.; Maksimoska, Jasna; Marmorstein, Ronen; Murray, Lesley J.; O’Brien, Thomas; Oh, Angela; Ramaswamy, Sreemathy; Wang, Weiru; Zhao, Xianrui; Zhong, Yu; Blackwood, Elizabeth; Rudolph, Joachim (2015). Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p K a Polar Moiety.
  • Ndubaku, Chudi O.; Crawford, Terry D.; Chen, Huifen; Boggs, Jason W.; Drobnick, Joy; Harris, Seth F.; Jesudason, Rajiv; McNamara, Erin; Nonomiya, Jim; Sambrone, Amy; Schmidt, Stephen; Smyczek, Tanya; Vitorino, Philip; Wang, Lan; Wu, Ping; Yeung, Stacey; Chen, Jinhua; Chen, Kevin; Ding, Charles Z.; Wang, Tao; Xu, Zijin; Gould, Stephen E.; Murray, Lesley J.; Ye, Weilan (2015). Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Medicinal Chemistry Letters , 150701131538007. 10.1021/acsmedchemlett.5b00174.
  • Parker, Aulma; Petluru, Pavankumar; Nienaber, Vicki; Badger, John; Leverett, Betsy; Jair, Kamwing; Sridhar, Vandana; Logan, Cheyenne; Ayala, Philippe; Kochat, Harry; Hausheer, Frederick (2015). Cysteine Specific Targeting of the Functionally Distinct Peroxiredoxin and Glutaredoxin Proteins by the Investigational Disulfide BNP7787. Molecules 20(3) , 4928-4950. 10.3390/molecules20034928.
  • Parker, Michelle L.; Penarete-Vargas, Diana M.; Hamilton, Phineas T.; Guérin, Amandine; Dubey, Jitender P.; Perlman, Steve J.; Spano, Furio; Lebrun, Maryse; Boulanger, Martin J. (2015). Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair. Proceedings of the National Academy of Sciences 113(2) , 398-403. 10.1073/pnas.1515898113. [PDB: 4z80, 4z81]
  • Pfoh, Roland; Lacdao, Ira Kay; Georges, Anna A.; Capar, Adam; Zheng, Hong; Frappier, Lori; Saridakis, Vivian (2015). Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7. PLoS Pathogens 11(6) , e1004950. 10.1371/journal.ppat.1004950. [PDB: 4wpi]
  • Piper, Derek E.; Romanow, William G.; Gunawardane, Ruwanthi N.; Fordstrom, Preston; Masterman, Stephanie; Pan, Oscar; Thibault, Stephen T.; Zhang, Richard; Meininger, David; Schwarz, Margrit; Wang, Zhulun; King, Chadwick; Zhou, Mingyue; Walker, Nigel P. C. (2015). The high-resolution crystal structure of human LCAT. The Journal of Lipid Research 56(9) , 1711-1719. 10.1194/jlr.m059873. [PDB: 4xwg]
  • Poorghorban, Masoomeh; Das, Umashankar; Alaidi, Osama; Chitanda, Jackson; Michel, Deborah; Dimmock, Jonathan; Verrall, Ronald; Grochulski, Pawel; Badea, Ildiko (2015). Characterization of the host–guest complex of a curcumin analog with β-cyclodextrin and β-cyclodextrin–gemini surfactant and evaluation of its anticancer activity. International Journal of Nanomedicine , 503. 10.2147/ijn.s70828.
  • Raheem, Izzat T.; Walji, Abbas M.; Klein, Daniel; Sanders, John M.; Powell, David A.; Abeywickrema, Pravien; Barbe, Guillaume; Bennet, Amrith; Clas, Sophie−Dorothee; Dubost, David; Embrey, Mark; Grobler, Jay; Hafey, Michael J.; Hartingh, Timothy J.; Hazuda, Daria J.; Miller, Michael D.; Moore, Keith P.; Pajkovic, Natasa; Patel, Sangita; Rada, Vanessa; Rearden, Paul; Schreier, John D.; Sisko, John; Steele, Thomas G.; Truchon, Jean-François; Wai, John; Xu, Min; Coleman, Paul J. (2015). Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors. Journal of Medicinal Chemistry 58(20) , 8154-8165. 10.1021/acs.jmedchem.5b01037. [PDB: 4ztf]
  • Ravulapalli, Ravikiran; Lugo, Miguel R.; Pfoh, Roland; Visschedyk, Danielle; Poole, Amanda; Fieldhouse, Robert J.; Pai, Emil F.; Merrill, A. Rod (2015). Characterization of Vis Toxin, a Novel ADP-Ribosyltransferase from Vibrio splendidus. Biochemistry 54(38) , 5920-5936. 10.1021/acs.biochem.5b00921. [PDB: 4y1w, 4yc0]
  • Reid, Joel; Bond, Toby; Wang, Shiliang; Zhou, Jigang; Hu, Anguang (2015). Synchrotron powder diffraction, X-ray absorption and 1H nuclear magnetic resonance data for hypoxanthine, C5H4N4O. Powder Diffraction , 1-8. 10.1017/s0885715615000457.
  • Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B. (2015). Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2. Journal of Medicinal Chemistry 58(4) , 1976-1991. 10.1021/jm501921k. [PDB: 4xj0]
  • Robb, Melissa; Robb, Craig S.; Higgins, Melanie A.; Hobbs, Joanne K; Paton, James C.; Boraston, Alisdair B. (2015). A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans. Journal of Biological Chemistry , jbc.M115.688630. 10.1074/jbc.m115.688630. [PDB: 5a6b, 5a6k, 5ac5]
  • Sanhueza, Carlos A.; Cartmell, Jonathan; El-Hawiet, Amr; Szpacenko, Adam; Kitova, Elena N.; Daneshfar, Rambod; Klassen, John S.; Lang, Dean E.; Eugenio, Luiz; Ng, Kenneth K.-S.; Kitov, Pavel I.; Bundle, David R. (2015). Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins. Organic & Biomolecular Chemistry 13(1) , 283-298. 10.1039/c4ob01838a.
  • Shi, Qiaojuan; Straus, Marco R.; Caron, Jeremy J.; Wang, Huasheng; Chung, Yu Seon; Guarné, Alba; Peters, Joseph E. (2015). Conformational toggling controls target site choice for the heteromeric transposase element Tn7. Nucleic Acids Research , gkv913. 10.1093/nar/gkv913. [PDB: 5d16]
  • Singh, Sheo B.; Kaelin, David E.; Wu, Jin; Miesel, Lynn; Tan, Christopher M.; Black, Todd; Nargund, Ravi; Meinke, Peter T.; Olsen, David B.; Lagrutta, Armando; Lu, Jun; Patel, Sangita; Rickert, Keith W.; Smith, Robert F.; Soisson, Stephen; Sherer, Edward; Joyce, Leo A.; Wei, Changqing; Peng, Xuanjia; Wang, Xiu; Fukuda, Hideyuki; Kishii, Ryuta; Takei, Masaya; Takano, Hisashi; Shibasaki, Mitsuhito; Yajima, Masanobu; Nishimura, Akinori; Shibata, Takeshi; Fukuda, Yasumichi (2015). Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2). Bioorganic & Medicinal Chemistry Letters 25(9) , 1831-1835. 10.1016/j.bmcl.2015.03.044. [PDB: 5bs3]
  • Sit, Brandon; Crowley, Shauna M.; Bhullar, Kirandeep; Lai, Christine Chieh-Lin; Tang, Calvin; Hooda, Yogesh; Calmettes, Charles; Khambati, Husain; Ma, Caixia; Brumell, John H.; Schryvers, Anthony B.; Vallance, Bruce A.; Moraes, Trevor F. (2015). Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen. PLoS Pathogens 11(8) , e1005107. 10.1371/journal.ppat.1005107. [PDB: 4r72, 4r73]
  • Sivaprakasam, Prasanna; Han, Xiaojun; Civiello, Rita L.; Jacutin-Porte, Swanee; Kish, Kevin; Pokross, Matt; Lewis, Hal A.; Ahmed, Nazia; Szapiel, Nicolas; Newitt, John A.; Baldwin, Eric T.; Xiao, Hong; Krause, Carol M.; Park, Hyunsoo; Nophsker, Michelle; Lippy, Jonathan S.; Burton, Catherine R.; Langley, David R.; Macor, John E.; Dubowchik, Gene M. (2015). Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorganic & Medicinal Chemistry Letters 25(9) , 1856-1863. 10.1016/j.bmcl.2015.03.046. [PDB: 4ptc]
  • Sobhanifar, Solmaz; Worrall, Liam James; Gruninger, Robert J.; Wasney, Gregory A.; Blaukopf, Markus; Baumann, Lars; Lameignere, Emilie; Solomonson, Matthew; Brown, Eric D.; Withers, Stephen G.; Strynadka, Natalie C. J. (2015). Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase. Proceedings of the National Academy of Sciences 112(6) , E576-E585. 10.1073/pnas.1418084112. [PDB: 4x7p, 4x6l, 4x7r, 4x7m]
  • Štrukil, Vjekoslav; Gracin, Davor; Magdysyuk, Oxana V.; Dinnebier, Robert E.; Friščić, Tomislav (2015). Trapping Reactive Intermediates by Mechanochemistry: Elusive Aryl N -Thiocarbamoylbenzotriazoles as Bench-Stable Reagents. Angewandte Chemie International Edition 54. 10.1002/anie.201502026.
  • Szewczyk, Paul; Tao, Houchao; McGrath, Aaron P.; Villaluz, Mark; Rees, Steven D.; Lee, Sung Chang; Doshi, Rupak; Urbatsch, Ina L.; Zhang, Qinghai; Chang, Geoffrey (2015). Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallographica Section D Biological Crystallography 71(3) , 732-741. 10.1107/s1399004715000978. [PDB: 4q9l, 4q9j, 4q9i]
  • Taylor, Alexander M.; Vaswani, Rishi G.; Gehling, Victor S.; Hewitt, Michael C.; Leblanc, Yves; Audia, James E.; Bellon, Steve; Cummings, Richard T.; Côté, Alexandre; Harmange, Jean-Christophe; Jayaram, Hari; Joshi, Shivangi; Lora, Jose M.; Mertz, Jennifer A.; Neiss, Adrianne; Pardo, Eneida; Nasveschuk, Christopher G.; Poy, Florence; Sandy, Peter; Setser, Jeremy W.; Sims, Robert J.; Tang, Yong; Albrecht, Brian K. (2015). Discovery of Benzotriazolo[4,3- d ][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains. ACS Medicinal Chemistry Letters , 150507113007003. 10.1021/ml500411h. [PDB: 4z1s]
  • Tokarski, John S.; Zupa-Fernandez, Adriana; Tredup, Jeffrey A.; Pike, Kristen; Chang, ChiehYing; Xie, Dianlin; Cheng, Lihong; Pedicord, Donna; Muckelbauer, Jodi; Johnson, Stephen R.; Wu, Sophie; Edavettal, Suzanne C.; Hong, Yang; Witmer, Mark R.; Elkin, Lisa L.; Blat, Yuval; Pitts, William J.; Weinstein, David S.; Burke, James R. (2015). Tyrosine Kinase 2-Mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of its Pseudokinase Domain. Journal of Biological Chemistry , jbc.M114.619502. 10.1074/jbc.m114.619502. [PDB: 4wov]
  • van Straaten, Karin E.; Kuttiyatveetil, Jijin R. A.; Sevrain, Charlotte M.; Villaume, Sydney A.; Jiménez-Barbero, Jesús; Linclau, Bruno; Vincent, Stéphane P.; Sanders, David A. R. (2015). Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues. Journal of the American Chemical Society , 150116151129006. 10.1021/ja511204p. [PDB: 4rpk, 4rpj, 4rpl, 4rpg, 4rph]
  • Volkers, Gesa; Worrall, Liam J; Kwan, David H; Yu, Ching-Ching; Baumann, Lars; Lameignere, Emilie; Wasney, Gregory A; Scott, Nichollas E; Wakarchuk, Warren; Foster, Leonard J; Withers, Stephen G; Strynadka, Natalie C J (2015). Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Nature Structural & Molecular Biology 22(8) , 627-635. 10.1038/nsmb.3060. [PDB: 5bo7, 5bo6, 5bo8]
  • Wan, Honghe; Schroeder, Gretchen M.; Hart, Amy C.; Inghrim, Jennifer; Grebinski, James; Tokarski, John S.; Lorenzi, Matthew V.; You, Dan; Mcdevitt, Theresa; Penhallow, Becky; Vuppugalla, Ragini; Zhang, Yueping; Gu, Xiaomei; Iyer, Ramaswamy; Lombardo, Louis J.; Trainor, George L.; Ruepp, Stefan; Lippy, Jonathan; Blat, Yuval; Sack, John S.; Khan, Javed A.; Stefanski, Kevin; Sleczka, Bogdan; Mathur, Arvind; Sun, Jung-Hui; Wong, Michael K.; Wu, Dauh-Rurng; Li, Peng; Gupta, Anuradha; Arunachalam, P. N.; Pragalathan, Bala; Narayanan, Sankara; K.C., Nanjundaswamy; Kuppusamy, Prakasam; Purandare, Ashok V. (2015). Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Medicinal Chemistry Letters 6(8) , 850-855. 10.1021/acsmedchemlett.5b00226. [PDB: 5cf8]
  • White, E. Railey; Sun, Luxin; Ma, Zhong; Beckta, Jason M.; Danzig, Brittany A.; Hacker, David E.; Huie, Melissa; Williams, David C.; Edwards, Ross A.; Valerie, Kristoffer; Glover, J. N. Mark; Hartman, Matthew C. T. (2015). Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. ACS Chemical Biology , 150205105827009. 10.1021/cb500757u. [PDB: 4ofb]
  • Xu, Chao; Li, Zhihong; He, Hao; Wernimont, Amy; Li, Yanjun; Loppnau, Peter; Min, Jinrong (2015). Crystal structure of human nuclear pore complex component NUP43. FEBS Letters 589(21) , 3247-3253. 10.1016/j.febslet.2015.09.008. [PDB: 4i79]
  • Yuchi, Zhiguang; Yuen, Siobhan M. Wong King; Lau, Kelvin; Underhill, Ainsley Q.; Cornea, Razvan L.; Fessenden, James D.; Van Petegem, Filip (2015). Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant. Nature Communications 6, 7947. 10.1038/ncomms8947.
  • Zhao, Jianbao; Liu, Zhenxian; Reid, Joel; Takarabe, Kenichi; Iida, Tsutomu; Wang, Bosen; Yoshiya, Uwatoko; Tse, John S. (2015). Thermoelectric and electrical transport properties of Mg 2 Si multi-doped with Sb, Al and Zn. Journal of Materials Chemistry A 3(39) , 19774-19782. 10.1039/c5ta03751d.

2014 

  • Anzar, Muhammad; Grochulski, Pawel; Bonnet, Brennan (2014). Synchrotron X-Ray Diffraction to Detect Glass or Ice Formation in the Vitrified Bovine Cumulus-Oocyte Complexes and Morulae. PLoS ONE 9(12) , e114801. 10.1371/journal.pone.0114801.
  • Bailey-Elkin, B. A.; Knaap, R. C. M.; Johnson, G. G.; Dalebout, T. J.; Ninaber, D. K.; van Kasteren, P. B.; Bredenbeek, P. J.; Snijder, E. J.; Kikkert, M.; Mark, B. L. (2014). Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. Journal of Biological Chemistry 289(50) , 34667-34682. 10.1074/jbc.m114.609644. [PDB: 4rf0, 4rf1, 4rez]
  • Bergeron, Julien R.C.; Worrall, Liam J.; De, Soumya; Sgourakis, Nikolaos G.; Cheung, Adrienne H.; Lameignere, Emilie; Okon, Mark; Wasney, Gregory A.; Baker, David; McIntosh, Lawrence P.; Strynadka, Natalie C.J. (2014). The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body. Structure 23(1) , 161-172. 10.1016/j.str.2014.10.021. [PDB: 4oyc, 4w4m]
  • Bertwistle, Drew; Vogt, Linda; Aamudalapalli, Hari Babu; Palmer, David R. J.; Sanders, David A. R. (2014). Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 from Lactobacillus casei BL23. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(7) , 979-983. 10.1107/s2053230x14011595.
  • Blattner, Claudia; Lee, Jeong Hyun; Sliepen, Kwinten; Derking, Ronald; Falkowska, Emilia; de la Peña, Alba Torrents; Cupo, Albert; Julien, Jean-Philippe; van Gils, Marit; Lee, Peter S.; Peng, Wenjie; Paulson, James C.; Poignard, Pascal; Burton, Dennis R.; Moore, John P.; Sanders, Rogier W.; Wilson, Ian A.; Ward, Andrew B. (2014). Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity 40(5) , 669-680. 10.1016/j.immuni.2014.04.008. [PDB: 4nug]
  • Cappadocia, Laurent; Mascle, Xavier H.; Bourdeau, Véronique; Tremblay-Belzile, Samuel; Chaker-Margot, Malik; Lussier-Price, Mathieu; Wada, Junya; Sakaguchi, Kazuyasu; Aubry, Muriel; Ferbeyre, Gerardo; Omichinski, James G. (2014). Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1. Structure 23(1) , 126-138. 10.1016/j.str.2014.10.015. [PDB: 4wjn]
  • Chamberlain, Philip P; Lopez-Girona, Antonia; Miller, Karen; Carmel, Gilles; Pagarigan, Barbra; Chie-Leon, Barbara; Rychak, Emily; Corral, Laura G; Ren, Yan J; Wang, Maria; Riley, Mariko; Delker, Silvia L; Ito, Takumi; Ando, Hideki; Mori, Tomoyuki; Hirano, Yoshinori; Handa, Hiroshi; Hakoshima, Toshio; Daniel, Thomas O; Cathers, Brian E (2014). Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nature Structural & Molecular Biology 21(9) , 803-809. 10.1038/nsmb.2874.
  • Chan, Anson C. K.; Blair, Kris M.; Liu, Yanjie; Frirdich, Emilisa; Gaynor, Erin C.; Tanner, Martin E.; Salama, Nina R.; Murphy, Michael E. P. (2014). Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4. Journal of Biological Chemistry , jbc.M114.624734. 10.1074/jbc.M114.624734. [PDB: 4wck, 4wcn, 4wcl, 4wcm]
  • Conly, Cuylar J. T.; Skovpen, Yulia V.; Li, Shuo; Palmer, David R. J.; Sanders, David A. R. (2014). Tyrosine 110 Plays a Critical Role in Regulating the Allosteric Inhibition of Campylobacter jejuni Dihydrodipicolinate Synthase by Lysine. Biochemistry 53(47) , 7396-7406. 10.1021/bi5012157. [PDB: 4m19, 4ly8, 4mlr, 4mlj, 4r53]
  • De Schutter, Joris W.; Park, Jaeok; Leung, Chun Yuen; Gormley, Patrick; Lin, Yih-Shyan; Hu, Zheping; Berghuis, Albert M.; Poirier, Judes; Tsantrizos, Youla S. (2014). Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases. Journal of Medicinal Chemistry 57(13) , 5764-5776. 10.1021/jm500629e. [PDB: 4lpg, 4lph]
  • Doores, Katie J.; Kong, Leopold; Krumm, Stefanie A.; Le, Khoa M.; Sok, Devin; Laserson, Uri; Garces, Fernando; Poignard, Pascal; Wilson, Ian A.; Burton, Dennis R. (2014). Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope. Journal of Virology 89(2) , 1105-1118. 10.1128/jvi.02905-14. [PDB: 4rnr]
  • Duan, James J.-W.; Lu, Zhonghui; Jiang, Bin; Yang, Bingwei V.; Doweyko, Lidia M.; Nirschl, David S.; Haque, Lauren E.; Lin, Shuqun; Brown, Gregory; Hynes, John; Tokarski, John S.; Sack, John S.; Khan, Javed; Lippy, Jonathan S.; Zhang, Rosemary F.; Pitt, Sidney; Shen, Guoxiang; Pitts, William J.; Carter, Percy H.; Barrish, Joel C.; Nadler, Steven G.; Salter-Cid, Luisa M.; McKinnon, Murray; Fura, Aberra; Schieven, Gary L.; Wrobleski, Stephen T. (2014). Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Bioorganic & Medicinal Chemistry Letters 24(24) , 5721-5726. 10.1016/j.bmcl.2014.10.061. [PDB: 4rio]
  • Elliott, J.Michael; Ultsch, Mark; Lee, Joshua; Tong, Raymond; Takeda, Kentaro; Spiess, Christoph; Eigenbrot, Charles; Scheer, Justin M. (2014). Antiparallel Conformation of Knob and Hole Aglycosylated Half-Antibody Homodimers Is Mediated by a CH2–CH3 Hydrophobic Interaction. Journal of Molecular Biology 426(9) , 1947-1957. 10.1016/j.jmb.2014.02.015. [PDB: 4nqt]
  • Fodje, Michel; Grochulski, Pawel; Janzen, Kathryn; Labiuk, Shaunivan; Gorin, James; Berg, Russ (2014). 08B1-1: an automated beamline for macromolecular crystallography experiments at the Canadian Light Source. Journal of Synchrotron Radiation 21(3) , 633-637. 10.1107/s1600577514005578.
  • Frandoloso, R.; Martinez-Martinez, S.; Calmettes, C.; Fegan, J.; Costa, E.; Curran, D.; Yu, R.-h.; Gutierrez-Martin, C. B.; Rodriguez Ferri, E. F.; Moraes, T. F.; Schryvers, A. B. (2014). Nonbinding site-directed mutants of transferrin binding protein B enhances their immunogenicity and protective capabilities. Infection and Immunity . 10.1128/IAI.02572-14. [PDB: 4o49, 4o4x, 4o4u, 4o3w, 4o3x, 4o3z, 4o3y]
  • Gobeil, Sophie M.C.; Clouthier, Christopher M.; Park, Jaeok; Gagné, Donald; Berghuis, Albert M.; Doucet, Nicolas; Pelletier, Joelle N. (2014). Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins. Chemistry & Biology 21(10) , 1330-1340. 10.1016/j.chembiol.2014.07.016. [PDB: 4id4]
  • Grishin, Andrey M.; Cherney, Maia; Anderson, Deborah H.; Phanse, Sadhna; Babu, Mohan; Cygler, Miroslaw (2014). NleH Defines a New Family of Bacterial Effector Kinases. Structure 22(2) , 250-259. 10.1016/j.str.2013.11.006. [PDB: 4lrj, 4lrk]
  • Grishin, Andrey M.; Condos, Tara E.C.; Barber, Kathryn R.; Campbell-Valois, François-Xavier; Parsot, Claude; Shaw, Gary S.; Cygler, Miroslaw (2014). Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG. Structure 22(6) , 878-888. 10.1016/j.str.2014.04.010. [PDB: 4q5e, 4q5h]
  • Groves, Michael N.; Malardier-Jugroot, Cecile; Jugroot, Manish (2014). Environmentally friendly synthesis of supportless Pt based nanoreactors in aqueous solution. Chemical Physics Letters 612, 309-312. 10.1016/j.cplett.2014.08.017.
  • Gruninger, Robert J.; Thibault, John; Capeness, Michael J.; Till, Robert; Mosimann, Steven C.; Sockett, R. Elizabeth; Selinger, Brent L.; Lovering, Andrew L. (2014). Structural and Biochemical Analysis of a Unique Phosphatase from Bdellovibrio bacteriovorus Reveals Its Structural and Functional Relationship with the Protein Tyrosine Phosphatase Class of Phytase. PLoS ONE 9(4) , e94403. 10.1371/journal.pone.0094403. [PDB: 4nx8]
  • Haji-Ghassemi, O.; Muller-Loennies, S.; Saldova, R.; Muniyappa, M.; Brade, L.; Rudd, P. M.; Harvey, D. J.; Kosma, P.; Brade, H.; Evans, S. V. (2014). Groove-type Recognition of Chlamydiaceae-specific Lipopolysaccharide Antigen by a Family of Antibodies Possessing an Unusual Variable Heavy Chain N-Linked Glycan. Journal of Biological Chemistry 289(24) , 16644-16661. 10.1074/jbc.m113.528224. [PDB: 4m93, 4m7j, 4m7z, 4ma1]
  • Hehemann, Jan-Hendrik; Law, Adrienne; Redecke, Lars; Boraston, Alisdair B. (2014). The Structure of RdDddP from Roseobacter denitrificans Reveals That DMSP Lyases in the DddP-Family Are Metalloenzymes. PLoS ONE 9(7) , e103128. 10.1371/journal.pone.0103128. [PDB: 4b28]
  • Higgins, Melanie A.; Suits, Michael D.; Marsters, Candace; Boraston, Alisdair B. (2014). Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus pneumoniae. Journal of Molecular Biology 426(7) , 1469-1482. 10.1016/j.jmb.2013.12.006. [PDB: 4c21, 4c22]
  • Huh, Ian; Gene, Robert; Kumaran, Jyothi; MacKenzie, C. Roger; Brooks, Cory L. (2014). In situ proteolysis, crystallization and preliminary X-ray diffraction analysis of a V H H that binds listeria internalin B. Acta Crystallographica Section F Structural Biology Communications 70(11) , 1532-1535. 10.1107/s2053230x1402010x.
  • Johnson, Ted W.; Richardson, Paul F.; Bailey, Simon; Brooun, Alexei; Burke, Benjamin J.; Collins, Michael R.; Cui, J. Jean; Deal, Judith G.; Deng, Ya-Li; Dinh, Dac; Engstrom, Lars D.; He, Mingying; Hoffman, Jacqui; Hoffman, Robert L.; Huang, Qinhua; Kania, Robert S.; Kath, John C.; Lam, Hieu; Lam, Justine L.; Le, Phuong T.; Lingardo, Laura; Liu, Wei; McTigue, Michele; Palmer, Cynthia L.; Sach, Neal W.; Smeal, Tod; Smith, Graham L.; Stewart, Albert E.; Timofeevski, Sergei; Zhu, Huichun; Zhu, Jinjiang; Zou, Helen Y.; Edwards, Martin P. (2014). Discovery of (10 R )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- 2H -8,4-(metheno)pyrazolo[4,3- h ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations. Journal of Medicinal Chemistry 57(11) , 4720-4744. 10.1021/jm500261q. [PDB: 4ctb]
  • Kalynych, Sergei; Cherney, Maia; Bostina, Mihnea; Rouiller, Isabelle; Cygler, Miroslaw (2014). Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Protein Science 24(1) , 58-69. 10.1002/pro.2586.
  • Keeling, Thomas J.; Samborska, Bożena; Demers, Ryan W.; Kimber, Matthew S. (2014). Interactions and structural variability of β-carboxysomal shell protein CcmL. Photosynthesis Research 121(2-3) , 125-133. 10.1007/s11120-014-9973-z. [PDB: 4n8x, 4n8f]
  • Khozeimeh Sarbisheh, Elaheh; Green, Jennifer C.; Müller, Jens (2014). Isomerization of an Enantiomerically Pure Phosphorus-Bridged [1]Ferrocenophane. Organometallics , 140623081557009. 10.1021/om500424m.
  • Kiefer, Susan E.; Chang, ChiehYing J.; Kimura, S. Roy; Gao, Mian; Xie, Dianlin; Zhang, Yaqun; Zhang, Guifen; Gill, Martin B.; Mastalerz, Harold; Thompson, Lorin A.; Cacace, Angela M.; Sheriff, Steven (2014). The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(2) , 173-181. 10.1107/s2053230x14000144.
  • King, D. T.; Lameignere, E.; Strynadka, N. C. J. (2014). Structural Insights into the Lipoprotein Outer Membrane Regulator of Penicillin-binding Protein 1B. Journal of Biological Chemistry 289(27) , 19245-19253. 10.1074/jbc.m114.565879. [PDB: 4q6v, 4q6z, 4q6l]
  • Krska, Daniel; Ravulapalli, Ravikiran; Fieldhouse, Robert J.; Lugo, Miguel R.; Merrill, A. Rod (2014). C3larvin Toxin, an ADP-ribosyltransferase from Paenibacillus larvae. Journal of Biological Chemistry 290(3) , 1639-1653. 10.1074/jbc.m114.589846.
  • Lau, Kelvin; Van Petegem, Filip (2014). Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain. Nature Communications 5, 5397. 10.1038/ncomms6397. [PDB: 4p9i]
  • Leung, Kevin K. K.; Shilton, Brian H. (2014). Quinone Reductase 2 Is an Adventitious Target of Protein Kinase CK2 Inhibitors TBBz (TBI) and DMAT. Biochemistry 54(1) , 47-59. 10.1021/bi500959t. [PDB: 4u7h]
  • Lewis, Steven M; Wu, Xiufeng; Pustilnik, Anna; Sereno, Arlene; Huang, Flora; Rick, Heather L; Guntas, Gurkan; Leaver-Fay, Andrew; Smith, Eric M; Ho, Carolyn; Hansen-Estruch, Christophe; Chamberlain, Aaron K; Truhlar, Stephanie M; Conner, Elaine M; Atwell, Shane; Kuhlman, Brian; Demarest, Stephen J (2014). Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nature Biotechnology 32(2) , 191-198. 10.1038/nbt.2797. [PDB: 4lld]
  • Little, D. J.; Li, G.; Ing, C.; DiFrancesco, B. R.; Bamford, N. C.; Robinson, H.; Nitz, M.; Pomes, R.; Howell, P. L. (2014). Modification and periplasmic translocation of the biofilm exopolysaccharide poly- -1,6-N-acetyl-D-glucosamine. Proceedings of the National Academy of Sciences 111(30) , 11013-11018. 10.1073/pnas.1406388111. [PDB: 4p7q, 4p7r]
  • Loewen, Peter C.; Carpena, Xavi; Vidossich, Pietro; Fita, Ignacio; Rovira, Carme (2014). An Ionizable Active-Site Tryptophan Imparts Catalase Activity to a Peroxidase Core. Journal of the American Chemical Society 136(20) , 7249-7252. 10.1021/ja502794e. [PDB: 4mvp, 5syk]
  • Man, Henry; Loderer, Christoph; Ansorge-Schumacher, Marion B.; Grogan, Gideon (2014). Structure of NADH-Dependent Carbonyl Reductase (CPCR2) from Candida parapsilosis Provides Insight into Mutations that Improve Catalytic Properties. ChemCatChem 6(4) , 1103-1111. 10.1002/cctc.201300788. [PDB: 4c4o]
  • Maynard, Andrew; Crosby, Renae M.; Ellis, Byron; Hamatake, Robert; Hong, Zhi; Johns, Brian A.; Kahler, Kirsten M.; Koble, Cecilia; Leivers, Anna; Leivers, Martin R.; Mathis, Amanda; Peat, Andrew J.; Pouliot, Jeffrey J.; Roberts, Christopher D.; Samano, Vicente; Schmidt, Rachel M.; Smith, Gary K.; Spaltenstein, Andrew; Stewart, Eugene L.; Thommes, Pia; Turner, Elizabeth M.; Voitenleitner, Christian; Walker, Jill T.; Waitt, Greg; Weatherhead, Jason; Weaver, Kurt; Williams, Shawn; Wright, Lois; Xiong, Zhiping Z.; Haigh, David; Shotwell, J. Brad (2014). Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. Journal of Medicinal Chemistry 57(5) , 1902-1913. 10.1021/jm400317w. [PDB: 4khr]
  • Oh, Angela; Ho, Yen-Ching; Zak, Mark; Liu, Yongbo; Chen, Xukun; Yuen, Po-wai; Zheng, Xiaozhang; Liu, Yichin; Dragovich, Peter S.; Wang, Weiru (2014). Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase. ChemBioChem 15(8) , 1121-1130. 10.1002/cbic.201402023. [PDB: 4o10, 4o0z]
  • Park, Jaeok; Lin, Yih-Shyan; Tsantrizos, Youla S.; Berghuis, Albert M. (2014). Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(3) , 299-304. 10.1107/s2053230x14002106. [PDB: 4lfv]
  • Parker, M. J.; Gomery, K.; Richard, G.; MacKenzie, C. R.; Cox, A. D.; Richards, J. C.; Evans, S. V. (2014). Structural basis for selective cross-reactivity in a bactericidal antibody against inner core lipooligosaccharide from Neisseria meningitidis. Glycobiology 24(5) , 442-449. 10.1093/glycob/cwu009. [PDB: 4c83, 4rqx]
  • Penfield, J. S.; Worrall, L. J.; Strynadka, N. C.; Eltis, L. D. (2014). Substrate Specificities and Conformational Flexibility of 3-Ketosteroid 9 -Hydroxylases. Journal of Biological Chemistry 289(37) , 25523-25536. 10.1074/jbc.m114.575886. [PDB: 4qck, 4qdd, 4qdf, 4qdc]
  • Persch, Elke; Bryson, Steve; Todoroff, Nickolay K.; Eberle, Christian; Thelemann, Jonas; Dirdjaja, Natalie; Kaiser, Marcel; Weber, Maria; Derbani, Hassan; Brun, Reto; Schneider, Gisbert; Pai, Emil F.; Krauth-Siegel, R. Luise; Diederich, François (2014). Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase. ChemMedChem , n/a-n/a. 10.1002/cmdc.201402032. [PDB: 4nev]
  • Reid, Joel W.; Kaduk, James A.; Garimella, Subrahmanyam V.; Tse, John S. (2014). Rietveld refinement using synchrotron powder diffraction data for curcumin, C21H20O6, and comparison with density functional theory. Powder Diffraction 30(01) , 67-75. 10.1017/s0885715614001018.
  • René, Olivier; Fauber, Benjamin P.; Boenig, Gladys de Leon; Burton, Brenda; Eidenschenk, Céline; Everett, Christine; Gobbi, Alberto; Hymowitz, Sarah G.; Johnson, Adam R.; Kiefer, James R.; Liimatta, Marya; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; Wallweber, Heidi A.; Wong, Harvey (2014). Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action. ACS Medicinal Chemistry Letters , 141223070836000. 10.1021/ml500420y. [PDB: 4wqp]
  • Roach, E. J.; Kimber, M. S.; Khursigara, C. M. (2014). Crystal Structure and Site-directed Mutational Analysis Reveals Key Residues Involved in Escherichia coli ZapA Function. Journal of Biological Chemistry 289(34) , 23276-23286. 10.1074/jbc.m114.561928. [PDB: 4p1m]
  • Singh, Anirudh K.; Pluvinage, Benjamin; Higgins, Melanie A.; Dalia, Ankur B.; Woodiga, Shireen A.; Flynn, Matthew; Lloyd, Audrey R.; Weiser, Jeffrey N.; Stubbs, Keith A.; Boraston, Alisdair B.; King, Samantha J. (2014). Unravelling the Multiple Functions of the Architecturally Intricate Streptococcus pneumoniae β-galactosidase, BgaA. PLoS Pathogens 10(9) , e1004364. 10.1371/journal.ppat.1004364. [PDB: 4cua, 4cuc, 4cu9]
  • Suits, M. D. L.; Pluvinage, B.; Law, A.; Liu, Y.; Palma, A. S.; Chai, W.; Feizi, T.; Boraston, A. B. (2014). Conformational Analysis of the Streptococcus pneumoniae Hyaluronate Lyase and Characterization of Its Hyaluronan-specific Carbohydrate-binding Module. Journal of Biological Chemistry 289(39) , 27264-27277. 10.1074/jbc.m114.578435. [PDB: 4d0q]
  • Tempel, W.; Grabovec, I.; MacKenzie, F.; Dichenko, Y. V.; Usanov, S. A.; Gilep, A. A.; Park, H.-W.; Strushkevich, N. (2014). Structural characterization of human cholesterol 7 -hydroxylase. The Journal of Lipid Research 55(9) , 1925-1932. 10.1194/jlr.m050765.
  • Thi, Nhung Nguyen; Offen, Wendy A.; Shareck, François; Davies, Gideon J.; Doucet, Nicolas (2014). Structure and Activity of the Streptomyces coelicolor A3(2) β- N -Acetylhexosaminidase Provides Further Insight into GH20 Family Catalysis and Inhibition. Biochemistry 53(11) , 1789-1800. 10.1021/bi401697j. [PDB: 4c7f]
  • Tonkin, M. L.; Beck, J. R.; Bradley, P. J.; Boulanger, M. J. (2014). The Inner Membrane Complex Sub-compartment Proteins Critical for Replication of the Apicomplexan Parasite Toxoplasma gondii Adopt a Pleckstrin Homology Fold. Journal of Biological Chemistry 289(20) , 13962-13973. 10.1074/jbc.m114.548891.
  • Vadlamani, Grishma; Thomas, Misty D.; Patel, Trushar R.; Donald, Lynda J.; Reeve, Thomas M.; Stetefeld, Jörg; Standing, Kenneth G.; Vocadlo, David J.; Mark, Brian L. (2014). The β-Lactamase Gene Regulator AmpR Is a Tetramer That Recognizes and Binds the d-Ala-d-Ala Motif of Its Repressor UDP- N -acetylmuramic Acid (MurNAc)-pentapeptide. Journal of Biological Chemistry 290(5) , 2630-2643. 10.1074/jbc.m114.618199. [PDB: 4wkm]
  • Vidossich, Pietro; Loewen, Peter C.; Carpena, Xavi; Fiorin, Giacomo; Fita, Ignacio; Rovira, Carme (2014). Binding of the Antitubercular Pro-Drug Isoniazid in the Heme Access Channel of Catalase-Peroxidase (KatG). A Combined Structural and Metadynamics Investigation. The Journal of Physical Chemistry B 118(11) , 2924-2931. 10.1021/jp4123425. [PDB: 4ka6, 5syi]
  • Wyrzucki, A.; Dreyfus, C.; Kohler, I.; Steck, M.; Wilson, I. A.; Hangartner, L. (2014). Alternative Recognition of the Conserved Stem Epitope in Influenza A Virus Hemagglutinin by a VH3-30-Encoded Heterosubtypic Antibody. Journal of Virology 88(12) , 7083-7092. 10.1128/jvi.00178-14. [PDB: 4py8]
  • Yachnin, Brahm J.; McEvoy, Michelle B.; MacCuish, Roderick J. D.; Morley, Krista L.; Lau, Peter C. K.; Berghuis, Albert M. (2014). Lactone-Bound Structures of Cyclohexanone Monooxygenase Provide Insight into the Stereochemistry of Catalysis. ACS Chemical Biology 9(12) , 2843-2851. 10.1021/cb500442e. [PDB: 4rg3]
  • Yao, Deqiang; Cherney, Maia; Cygler, Miroslaw (2014). Structure of the N-terminal domain of the effector protein LegC3 from Legionella pneumophila. Acta Crystallographica Section D Biological Crystallography 70(2) , 436-441. 10.1107/s139900471302991x. [PDB: 4mu6]
  • Yao, Deqiang; Zhang, Tao; He, Yao; Han, Pu; Cherney, Maia; Gu, Yuanxin; Cygler, Miroslaw; Fan, Haifu (2014). A case study on the treatment of protein SIRAS data. Acta Crystallographica Section D Biological Crystallography 70(10) , 2686-2691. 10.1107/s1399004714017271.
  • Zamyatkin, Dmitry; Rao, Chandni; Hoffarth, Elesha; Jurca, Gabriela; Rho, Hayeong; Parra, Francisco; Grochulski, Pawel; Ng, Kenneth Kai-Sing (2014). Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase. Acta Crystallographica Section D Biological Crystallography 70(12) , 3099-3109. 10.1107/s1399004714021518. [PDB: 4qpx]
  • Zheng, Xiaozhang; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Lin, Jian; Reynolds, Dominic J.; Sharma, Geeta; Smith, Chase C.; Wang, Zhongguo; Dragovich, Peter S.; Oh, Angela; Wang, Weiru; Zak, Mark; Wang, Yunli; Yuen, Po-wai; Bair, Kenneth W. (2014). Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorganic & Medicinal Chemistry Letters 24(1) , 337-343. 10.1016/j.bmcl.2013.11.006. [PDB: 4lww]

2013 

  • Abbas, Yazan M.; Pichlmair, Andreas; Górna, Maria W.; Superti-Furga, Giulio; Nagar, Bhushan (2013). Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins. Nature 494(7435) , 60-64. 10.1038/nature11783. [PDB: 4hou, 4hoq]
  • Amador, Fernando J.; Kimlicka, Lynn; Stathopulos, Peter B.; Gasmi-Seabrook, Geneviève M.C.; MacLennan, David H.; Van Petegem, Filip; Ikura, Mitsuhiko (2013). Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy. Journal of Molecular Biology 425(21) , 4034-4046. 10.1016/j.jmb.2013.08.015. [PDB: 4kei, 4kej, 4kek]
  • Awad, Mark M.; Katayama, Ryohei; McTigue, Michele; Liu, Wei; Deng, Ya-Li; Brooun, Alexei; Friboulet, Luc; Huang, Donghui; Falk, Matthew D.; Timofeevski, Sergei; Wilner, Keith D.; Lockerman, Elizabeth L.; Khan, Tahsin M.; Mahmood, Sidra; Gainor, Justin F.; Digumarthy, Subba R.; Stone, James R.; Mino-Kenudson, Mari; Christensen, James G.; Iafrate, A. John; Engelman, Jeffrey A.; Shaw, Alice T. (2013). Acquired Resistance to Crizotinib from a Mutation in CD74 – ROS1. New England Journal of Medicine 368(25) , 2395-2401. 10.1056/nejmoa1215530. [PDB: 3zbf]
  • Aydin, H.; Smrke, B. M.; Lee, J. E. (2013). Structural characterization of a fusion glycoprotein from a retrovirus that undergoes a hybrid 2-step entry mechanism. The FASEB Journal 27(12) , 5059-5071. 10.1096/fj.13-232371. [PDB: 5h9c]
  • Bacik, J.-P.; Tavassoli, M.; Patel, T. R.; McKenna, S. A.; Vocadlo, D. J.; Khajehpour, M.; Mark, B. L. (2013). Conformational Itinerary of Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase during Its Catalytic Cycle. Journal of Biological Chemistry 289(7) , 4504-4514. 10.1074/jbc.m113.521633. [PDB: 4mo4, 4mo5]
  • Barrette-Ng, Isabelle H.; Wu, Sau-Ching; Tjia, Wai-Mui; Wong, Sui-Lam; Ng, Kenneth K. S. (2013). The structure of the SBP-Tag–streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits. Acta Crystallographica Section D Biological Crystallography 69(5) , 879-887. 10.1107/s0907444913002576.
  • Bergeron, Julien R. C.; Worrall, Liam J.; Sgourakis, Nikolaos G.; DiMaio, Frank; Pfuetzner, Richard A.; Felise, Heather B.; Vuckovic, Marija; Yu, Angel C.; Miller, Samuel I.; Baker, David; Strynadka, Natalie C. J. (2013). A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly. PLoS Pathogens 9(4) , e1003307. 10.1371/journal.ppat.1003307. [PDB: 4g2s, 4g1i, 4g08]
  • Bie, Haiying; Yin, Jiang; He, Xu; Kermode, Allison R; Goddard-Borger, Ethan D; Withers, Stephen G; James, Michael N G (2013). Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase. Nature Chemical Biology 9(11) , 739-745. 10.1038/nchembio.1357. [PDB: 4mj4, 4mj2]
  • Carere, Jason; McKenna, Sarah E.; Kimber, Matthew S.; Seah, Stephen Y. K. (2013). Characterization of an Aldolase–Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis. Biochemistry 52(20) , 3502-3511. 10.1021/bi400351h. [PDB: 4jn6]
  • Chung, I. Y. W.; Paetzel, M. (2013). Crystal Structures of Yellowtail Ascites Virus VP4 Protease: TRAPPING AN INTERNAL CLEAVAGE SITE TRANS ACYL-ENZYME COMPLEX IN A NATIVE SER/LYS DYAD ACTIVE SITE. Journal of Biological Chemistry 288(18) , 13068-13081. 10.1074/jbc.m112.386953. [PDB: 4izk]
  • Dalrymple, Sean A.; Ko, John; Sheoran, Inder; Kaminskyj, Susan G. W.; Sanders, David A. R. (2013). Elucidation of Substrate Specificity in Aspergillus nidulans UDP-Galactose-4-Epimerase. PLoS ONE 8(10) , e76803. 10.1371/journal.pone.0076803. [PDB: 4lis]
  • Du, Liqin; Luo, Yu (2013). Structure of a filament of stacked octamers of human DMC1 recombinase. Acta Crystallographica Section F Structural Biology and Crystallization Communications 69(4) , 382-386. 10.1107/s1744309113005678. [PDB: 4hyy]
  • Ernst, A.; Avvakumov, G.; Tong, J.; Fan, Y.; Zhao, Y.; Alberts, P.; Persaud, A.; Walker, J. R.; Neculai, A.-M.; Neculai, D.; Vorobyov, A.; Garg, P.; Beatty, L.; Chan, P.-K.; Juang, Y.-C.; Landry, M.-C.; Yeh, C.; Zeqiraj, E.; Karamboulas, K.; Allali-Hassani, A.; Vedadi, M.; Tyers, M.; Moffat, J.; Sicheri, F.; Pelletier, L.; Durocher, D.; Raught, B.; Rotin, D.; Yang, J.; Moran, M. F.; Dhe-Paganon, S.; Sidhu, S. S. (2013). A Strategy for Modulation of Enzymes in the Ubiquitin System. Science 339(6119) , 590-595. 10.1126/science.1230161. [PDB: 3n3k]
  • Ghosh, Kaushik; Mazumder Tagore, Debarati; Anumula, Rushith; Lakshmaiah, Basanth; Kumar, P.P.B.S.; Singaram, Senthuran; Matan, Thangavelu; Kallipatti, Sanjith; Selvam, Sabariya; Krishnamurthy, Prasad; Ramarao, Manjunath (2013). Crystal structure of rat intestinal alkaline phosphatase – Role of crown domain in mammalian alkaline phosphatases. Journal of Structural Biology 184(2) , 182-192. 10.1016/j.jsb.2013.09.017. [PDB: 4kjg]
  • Gonzalez-Lopez de Turiso, Felix; Sun, Daqing; Rew, Yosup; Bartberger, Michael D.; Beck, Hilary P.; Canon, Jude; Chen, Ada; Chow, David; Correll, Tiffany L.; Huang, Xin; Julian, Lisa D.; Kayser, Frank; Lo, Mei-Chu; Long, Alexander M.; McMinn, Dustin; Oliner, Jonathan D.; Osgood, Tao; Powers, Jay P.; Saiki, Anne Y.; Schneider, Steve; Shaffer, Paul; Xiao, Shou-Hua; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Medina, Julio C.; Olson, Steven H. (2013). Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors. Journal of Medicinal Chemistry 56(10) , 4053-4070. 10.1021/jm400293z. [PDB: 4jwr]
  • Grishin, Andrey M.; Ajamian, Eunice; Tao, Limei; Bostina, Mihnea; Zhang, Linhua; Trempe, Jean-Francois; Menard, Robert; Rouiller, Isabelle; Cygler, Miroslaw (2013). Family of phenylacetyl-CoA monooxygenases differs in subunit organization from other monooxygenases. Journal of Structural Biology 184(2) , 147-154. 10.1016/j.jsb.2013.09.012. [PDB: 4iit]
  • Guo, Chuangxing; Linton, Angelica; Jalaie, Mehran; Kephart, Susan; Ornelas, Martha; Pairish, Mason; Greasley, Samantha; Richardson, Paul; Maegley, Karen; Hickey, Michael; Li, John; Wu, Xin; Ji, Xiaodong; Xie, Zhi (2013). Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorganic & Medicinal Chemistry Letters 23(11) , 3358-3363. 10.1016/j.bmcl.2013.03.090. [PDB: 4jpg]
  • Hong, M.; Lee, P. S.; Hoffman, R. M. B.; Zhu, X.; Krause, J. C.; Laursen, N. S.; Yoon, S.-i.; Song, L.; Tussey, L.; Crowe, J. E.; Ward, A. B.; Wilson, I. A. (2013). Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site. Journal of Virology 87(22) , 12471-12480. 10.1128/jvi.01388-13. [PDB: 4m5z]
  • Hoover, Gordon J.; Jørgensen, René; Rochon, Amanda; Bajwa, Vikramjit S.; Merrill, A. Rod; Shelp, Barry J. (2013). Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834(12) , 2663-2671. 10.1016/j.bbapap.2013.09.013.
  • Hou, J.; Townson, S. A.; Kovalchin, J. T.; Masci, A.; Kiner, O.; Shu, Y.; King, B. M.; Schirmer, E.; Golden, K.; Thomas, C.; Garcia, K. C.; Zarbis-Papastoitsis, G.; Furfine, E. S.; Barnes, T. M. (2013). Design of a superior cytokine antagonist for topical ophthalmic use. Proceedings of the National Academy of Sciences 110(10) , 3913-3918. 10.1073/pnas.1217996110. [PDB: 4gaf, 4gai]
  • Iancu, C. V.; Zamoon, J.; Woo, S. B.; Aleshin, A.; Choe, J.-y. (2013). Crystal structure of a glucose/H+ symporter and its mechanism of action. Proceedings of the National Academy of Sciences 110(44) , 17862-17867. 10.1073/pnas.1311485110.
  • Jacobson, J. M.; Yin, J.; Kitov, P. I.; Mulvey, G.; Griener, T. P.; James, M. N. G.; Armstrong, G.; Bundle, D. R. (2013). The Crystal Structure of Shiga Toxin Type 2 with Bound Disaccharide Guides the Design of a Heterobifunctional Toxin Inhibitor. Journal of Biological Chemistry 289(2) , 885-894. 10.1074/jbc.m113.518886. [PDB: 4m1u]
  • Johal, A. R.; Blackler, R. J.; Alfaro, J. A.; Schuman, B.; Borisova, S.; Evans, S. V. (2013). pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state. Glycobiology 24(3) , 237-246. 10.1093/glycob/cwt098. [PDB: 4frp, 4frq, 4fre, 4frh, 4fro, 4frl, 4frm]
  • Julien, J.-P.; Cupo, A.; Sok, D.; Stanfield, R. L.; Lyumkis, D.; Deller, M. C.; Klasse, P.-J.; Burton, D. R.; Sanders, R. W.; Moore, J. P.; Ward, A. B.; Wilson, I. A. (2013). Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer. Science 342(6165) , 1477-1483. 10.1126/science.1245625.
  • Keszei, A. F. A.; Tang, X.; McCormick, C.; Zeqiraj, E.; Rohde, J. R.; Tyers, M.; Sicheri, F. (2013). Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase. Molecular and Cellular Biology 34(3) , 362-373. 10.1128/mcb.01360-13. [PDB: 4nkg]
  • Kimlicka, Lynn; Lau, Kelvin; Tung, Ching-Chieh; Van Petegem, Filip (2013). Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface. Nature Communications 4, 1506. 10.1038/ncomms2501. [PDB: 4i6i, 4i2s, 4i0y, 4i8m, 4i1e, 4i7i, 4i37]
  • Kimlicka, Lynn; Tung, Ching-Chieh; Carlsson, Anna-Carin Cecilia; Lobo, Paolo Antonio; Yuchi, Zhiguang; Van Petegem, Filip (2013). The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations. Structure 21(8) , 1440-1449. 10.1016/j.str.2013.06.012.
  • Lazareno-Saez, Christelle; Arutyunova, Elena; Coquelle, Nicolas; Lemieux, M. Joanne (2013). Domain Swapping in the Cytoplasmic Domain of the Escherichia coli Rhomboid Protease. Journal of Molecular Biology 425(7) , 1127-1142. 10.1016/j.jmb.2013.01.019. [PDB: 4hdd]
  • Lee, J.; Taneva, S. G.; Holland, B. W.; Tieleman, D. P.; Cornell, R. B. (2013). Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix. Journal of Biological Chemistry 289(3) , 1742-1755. 10.1074/jbc.m113.526970. [PDB: 4mvc, 4mvd]
  • Leung, Charles Chung Yun; Sun, Luxin; Gong, Zihua; Burkat, Michael; Edwards, Ross; Assmus, Mark; Chen, Junjie; Glover, J.N. Mark (2013). Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control. Structure 21(8) , 1450-1459. 10.1016/j.str.2013.06.015. [PDB: 3ueo]
  • Leung, Chun Yuen; Park, Jaeok; De Schutter, Joris W.; Sebag, Michael; Berghuis, Albert M.; Tsantrizos, Youla S. (2013). Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. Journal of Medicinal Chemistry 56(20) , 7939-7950. 10.1021/jm400946f. [PDB: 4jvj, 4l2x]
  • Leung, K. K. K.; Shilton, B. H. (2013). Chloroquine Binding Reveals Flavin Redox Switch Function of Quinone Reductase 2. Journal of Biological Chemistry 288(16) , 11242-11251. 10.1074/jbc.m113.457002.
  • Martynowski, Dariusz; Grochulski, Pawel; Howard, Peter S. (2013). Structure of a periplasmic domain of the EpsAB fusion protein of the Vibrio vulnificus type II secretion system. Acta Crystallographica Section D Biological Crystallography 69(2) , 142-149. 10.1107/s0907444912042710. [PDB: 4g54]
  • Mondon, Martine; Hur, Soo; Vadlamani, Grishma; Rodrigues, Prerana; Tsybina, Polina; Oliver, Antonio; Mark, Brian L.; Vocadlo, David J.; Blériot, Yves (2013). Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications 49(93) , 10983. 10.1039/c3cc46646a.
  • Murase, T.; Eugenio, L.; Schorr, M.; Hussack, G.; Tanha, J.; Kitova, E. N.; Klassen, J. S.; Ng, K. K. S. (2013). Structural Basis for Antibody Recognition in the Receptor-binding Domains of Toxins A and B from Clostridium difficile. Journal of Biological Chemistry 289(4) , 2331-2343. 10.1074/jbc.m113.505917. [PDB: 4nbx, 4nby, 4nc1]
  • Nakamura, Gerald; Chai, Ning; Park, Summer; Chiang, Nancy; Lin, Zhonghua; Chiu, Henry; Fong, Rina; Yan, Donghong; Kim, Janice; Zhang, Juan; Lee, Wyne P.; Estevez, Alberto; Coons, Mary; Xu, Min; Lupardus, Patrick; Balazs, Mercedesz; Swem, Lee R. (2013). An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies. Cell Host & Microbe 14(1) , 93-103. 10.1016/j.chom.2013.06.004. [PDB: 4kvn]
  • Nam, Sung-Eun; Paetzel, Mark (2013). Structure of Signal Peptide Peptidase A with C-Termini Bound in the Active Sites: Insights into Specificity, Self-Processing, and Regulation. Biochemistry 52(49) , 8811-8822. 10.1021/bi4011489. [PDB: 4kwb]
  • Pantua, Homer; Diao, Jingyu; Ultsch, Mark; Hazen, Meredith; Mathieu, Mary; McCutcheon, Krista; Takeda, Kentaro; Date, Shailesh; Cheung, Tommy K.; Phung, Qui; Hass, Phil; Arnott, David; Hongo, Jo-Anne; Matthews, David J.; Brown, Alex; Patel, Arvind H.; Kelley, Robert F.; Eigenbrot, Charles; Kapadia, Sharookh B. (2013). Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies. Journal of Molecular Biology 425(11) , 1899-1914. 10.1016/j.jmb.2013.02.025. [PDB: 4hs6]
  • Pluvinage, B.; Hehemann, J.-H.; Boraston, A. B. (2013). Substrate Recognition and Hydrolysis by a Family 50 exo- -Agarase, Aga50D, from the Marine Bacterium Saccharophagus degradans. Journal of Biological Chemistry 288(39) , 28078-28088. 10.1074/jbc.m113.491068. [PDB: 4bq5, 4bq4]
  • Poulin, Myles B.; Shi, Yun; Protsko, Carla; Dalrymple, Sean A.; Sanders, David A. R.; Pinto, B. Mario; Lowary, Todd L. (2013). Specificity of a UDP-GalNAc Pyranose-Furanose Mutase: A Potential Therapeutic Target for Campylobacter jejuni Infections. ChemBioChem 15(1) , 47-56. 10.1002/cbic.201300653. [PDB: 4mo2]
  • Recht, M. I.; Sridhar, V.; Badger, J.; Bounaud, P.-Y.; Logan, C.; Chie-Leon, B.; Nienaber, V.; Torres, F. E. (2013). Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. Journal of Biomolecular Screening 19(4) , 497-507. 10.1177/1087057113516493. [PDB: 4mrz, 4ms0, 4mse, 4msa, 4msc, 4mrw]
  • Saer, Rafael G.; Hardjasa, Amelia; Rosell, Federico I.; Mauk, A. Grant; Murphy, Michael E. P.; Beatty, J. Thomas (2013). Role of Rhodobacter sphaeroides Photosynthetic Reaction Center Residue M214 in the Composition, Absorbance Properties, and Conformations of H A and B A Cofactors. Biochemistry 52(13) , 2206-2217. 10.1021/bi400207m. [PDB: 4in5]
  • Safaee, Nozhat; Noronha, Anne M.; Rodionov, Dmitry; Kozlov, Guennadi; Wilds, Christopher J.; Sheldrick, George M.; Gehring, Kalle (2013). Structure of the Parallel Duplex of Poly(A) RNA: Evaluation of a 50 Year-Old Prediction. Angewandte Chemie International Edition 52(39) , 10370-10373. 10.1002/anie.201303461.
  • Schellenberg, Matthew J; Wu, Tao; Ritchie, Dustin B; Fica, Sebastian; Staley, Jonathan P; Atta, Karim A; LaPointe, Paul; MacMillan, Andrew M (2013). A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nature Structural & Molecular Biology 20(6) , 728-734. 10.1038/nsmb.2556. [PDB: 4jkh, 4jkc, 4jkb, 4jka, 4jk9, 4jk8, 4jk7]
  • Schmidt, Michael M.; Townson, Sharon A.; Andreucci, Amy J.; King, Bracken M.; Schirmer, Emily B.; Murillo, Alec J.; Dombrowski, Christian; Tisdale, Alison W.; Lowden, Patricia A.; Masci, Allyson L.; Kovalchin, Joseph T.; Erbe, David V.; Wittrup, K. Dane; Furfine, Eric S.; Barnes, Thomas M. (2013). Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface. Structure 21(11) , 1966-1978. 10.1016/j.str.2013.08.022. [PDB: 4k71]
  • Shala, Agnesa; Patel, Kevin H.; Golemi-Kotra, Dasantila; Audette, Gerald F. (2013). Expression, purification, crystallization and preliminary X-ray analysis of the receiver domain of Staphylococcus aureus LytR protein. Acta Crystallographica Section F Structural Biology and Crystallization Communications 69(12) , 1418-1421. 10.1107/s1744309113030972.
  • Solomonson, M.; Huesgen, P. F.; Wasney, G. A.; Watanabe, N.; Gruninger, R. J.; Prehna, G.; Overall, C. M.; Strynadka, N. C. J. (2013). Structure of the Mycosin-1 Protease from the Mycobacterial ESX-1 Protein Type VII Secretion System. Journal of Biological Chemistry 288(24) , 17782-17790. 10.1074/jbc.m113.462036. [PDB: 4j94, 4kpg]
  • Strushkevich, Natallia; Gilep, Andrei A.; Shen, Limin; Arrowsmith, Cheryl H.; Edwards, Aled M.; Usanov, Sergey A.; Park, Hee-Won (2013). Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition. Molecular Endocrinology 27(2) , 315-324. 10.1210/me.2012-1287. [PDB: 4dvq]
  • Stubbs, Keith A.; Bacik, John-Paul; Perley-Robertson, G. Evan; Whitworth, Garrett E.; Gloster, Tracey M.; Vocadlo, David J.; Mark, Brian L. (2013). The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams. ChemBioChem 14(15) , 1973-1981. 10.1002/cbic.201300395. [PDB: 4hzm]
  • Suits, Michael D.; Boraston, Alisdair B. (2013). Structure of the Streptococcus pneumoniae Surface Protein and Adhesin PfbA. PLoS ONE 8(7) , e67190. 10.1371/journal.pone.0067190. [PDB: 3zpp]
  • Sweeting, Braden; Brown, Eric; Khan, M. Qasim; Chakrabartty, Avijit; Pai, Emil F. (2013). N-Terminal Helix-Cap in α-Helix 2 Modulates β-State Misfolding in Rabbit and Hamster Prion Proteins. PLoS ONE 8(5) , e63047. 10.1371/journal.pone.0063047. [PDB: 4hmm, 4hls, 4hmr]
  • Tchigvintsev, Anatoli; Tchigvintsev, Dmitri; Flick, Robert; Popovic, Ana; Dong, Aiping; Xu, Xiaohui; Brown, Greg; Lu, Wenyun; Wu, Hong; Cui, Hong; Dombrowski, Ludmila; Joo, Jeong Chan; Beloglazova, Natalia; Min, Jinrong; Savchenko, Alexei; Caudy, Amy A.; Rabinowitz, Joshua D.; Murzin, Alexey G.; Yakunin, Alexander F. (2013). Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides. Chemistry & Biology 20(11) , 1386-1398. 10.1016/j.chembiol.2013.09.011. [PDB: 4heb]
  • Trempe, J.-F.; Sauve, V.; Grenier, K.; Seirafi, M.; Tang, M. Y.; Menade, M.; Al-Abdul-Wahid, S.; Krett, J.; Wong, K.; Kozlov, G.; Nagar, B.; Fon, E. A.; Gehring, K. (2013). Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation. Science 340(6139) , 1451-1455. 10.1126/science.1237908. [PDB: 4k7d]
  • van Kasteren, P. B.; Bailey-Elkin, B. A.; James, T. W.; Ninaber, D. K.; Beugeling, C.; Khajehpour, M.; Snijder, E. J.; Mark, B. L.; Kikkert, M. (2013). Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proceedings of the National Academy of Sciences 110(9) , E838-E847. 10.1073/pnas.1218464110. [PDB: 4ium]
  • van Straaten, K. E.; Ko, J. B.; Jagdhane, R.; Anjum, S.; Palmer, D. R. J.; Sanders, D. A. R. (2013). The Structure of NtdA, a Sugar Aminotransferase Involved in the Kanosamine Biosynthetic Pathway in Bacillus subtilis, Reveals a New Subclass of Aminotransferases. Journal of Biological Chemistry 288(47) , 34121-34130. 10.1074/jbc.m113.500637. [PDB: 4k2b, 4k2i, 4k2m]
  • Vinaik, Roohi; Kozlov, Guennadi; Gehring, Kalle (2013). Structure of the Non-Catalytic Domain of the Protein Disulfide Isomerase-Related Protein (PDIR) Reveals Function in Protein Binding. PLoS ONE 8(4) , e62021. 10.1371/journal.pone.0062021.
  • Von Kreudenstein, Thomas Spreter; Escobar-Carbrera, Eric; Lario, Paula I.; D’Angelo, Igor; Brault, Karine; Kelly, John; Durocher, Yves; Baardsnes, Jason; Woods, R. Jeremy; Xie, Michael Hongwei; Girod, Pierre-Alain; Suits, Michael D. L.; Boulanger, Martin J.; Poon, David K. Y.; Ng, Gordon Y.K.; Dixit, Surjit B. (2013). Improving biophysical properties of a bispecific antibody scaffold to aid developability: Quality by molecular design. mAbs 5(5) , 646-654. 10.4161/mabs.25632. [PDB: 4bsw, 4bsv]
  • Wheatley, R. W.; Lo, S.; Jancewicz, L. J.; Dugdale, M. L.; Huber, R. E. (2013). Structural Explanation for Allolactose (lac Operon Inducer) Synthesis by lacZ  -Galactosidase and the Evolutionary Relationship between Allolactose Synthesis and the lac Repressor. Journal of Biological Chemistry 288(18) , 12993-13005. 10.1074/jbc.m113.455436. [PDB: 4duw, 4dux]
  • Wu, Hong; Siarheyeva, Alena; Zeng, Hong; Lam, Robert; Dong, Aiping; Wu, Xian-Hui; Li, Yanjun; Schapira, Matthieu; Vedadi, Masoud; Min, Jinrong (2013). Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. FEBS Letters 587(23) , 3859-3868. 10.1016/j.febslet.2013.10.020. [PDB: 3s8p]
  • Wu, Hong; Zeng, Hong; Dong, Aiping; Li, Fengling; He, Hao; Senisterra, Guillermo; Seitova, Alma; Duan, Shili; Brown, Peter J.; Vedadi, Masoud; Arrowsmith, Cheryl H.; Schapira, Matthieu (2013). Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations. PLoS ONE 8(12) , e83737. 10.1371/journal.pone.0083737.
  • Zhang, Xiaolu Linda; Tibbits, Glen F.; Paetzel, Mark (2013). The structure of cardiac troponin C regulatory domain with bound Cd 2+ reveals a closed conformation and unique ion coordination. Acta Crystallographica Section D Biological Crystallography 69(5) , 722-734. 10.1107/s0907444913001182. [PDB: 3sd6, 4gje, 4gjg, 4gjf]
  • Zheng, Hongyan; Bertwistle, Drew; Sanders, David A. R.; Palmer, David R. J. (2013). Converting NAD-Specific Inositol Dehydrogenase to an Efficient NADP-Selective Catalyst, with a Surprising Twist. Biochemistry 52(34) , 5876-5883. 10.1021/bi400821s. [PDB: 4l8v, 4l9r]
  • Zheng, Xiaozhang; Bair, Kenneth W.; Bauer, Paul; Baumeister, Timm; Bowman, Krista K.; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Feng, Yezhen; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Li, Hong; Liang, Xiaorong; Liederer, Bianca M.; Lin, Jian; Ly, Justin; O’Brien, Thomas; Oeh, Jason; Oh, Angela; Reynolds, Dominic J.; Sampath, Deepak; Sharma, Geeta; Skelton, Nicholas; Smith, Chase C.; Tremayne, Jarrod; Wang, Leslie; Wang, Weiru; Wang, Zhongguo; Wu, Hongxing; Wu, Jiansheng; Xiao, Yang; Yang, Guangxing; Yuen, Po-wai; Zak, Mark; Dragovich, Peter S. (2013). Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters 23(20) , 5488-5497. 10.1016/j.bmcl.2013.08.074. [PDB: 4lva]
  • Zhu, X.; Yu, W.; McBride, R.; Li, Y.; Chen, L.-M.; Donis, R. O.; Tong, S.; Paulson, J. C.; Wilson, I. A. (2013). Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities. Proceedings of the National Academy of Sciences 110(4) , 1458-1463. 10.1073/pnas.1218509110. [PDB: 4i78]

2012 

  • Adams-Cioaba, Melanie A.; Li, Zhihong; Tempel, Wolfram; Guo, Yahong; Bian, Chuanbing; Li, Yanjun; Lam, Robert; Min, Jinrong (2012). Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins. FEBS Letters 586(6) , 859-865. 10.1016/j.febslet.2012.02.012. [PDB: 3qii]
  • Amunugama, R.; He, Y.; Willcox, S.; Forties, R. A.; Shim, K.-S.; Bundschuh, R.; Luo, Y.; Griffith, J.; Fishel, R. (2012). RAD51 Protein ATP Cap Regulates Nucleoprotein Filament Stability. Journal of Biological Chemistry 287(12) , 8724-8736. 10.1074/jbc.m111.239426. [PDB: 3ntu]
  • Axerio-Cilies, Peter; See, Raymond H; Zoraghi, Roya; Worral, Liam; Lian, Tian; Stoynov, Nikolay; Jiang, Jihong; Kaur, Sukhbir; Jackson, Linda; Gong, Huansheng; Swayze, Rick; Amandoron, Emily; Kumar, Nag S.; Moreau, Anne; Hsing, Michael; Strynadka, Natalie C.; McMaster, William R.; Finlay, B. Brett; Foster, Leonard J; Young, Robert N.; Reiner, Neil E.; Cherkasov, Artem (2012). Cheminformatics-Driven Discovery of Selective, Nanomolar Inhibitors for Staphylococcal Pyruvate Kinase. ACS Chemical Biology 7(2) , 350-359. 10.1021/cb2003576. [PDB: 3t0t]
  • Azoitei, Mihai L.; Ban, Yih-En Andrew; Julien, Jean-Philippe; Bryson, Steve; Schroeter, Alexandria; Kalyuzhniy, Oleksandr; Porter, Justin R.; Adachi, Yumiko; Baker, David; Pai, Emil F.; Schief, William R. (2012). Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope. Journal of Molecular Biology 415(1) , 175-192. 10.1016/j.jmb.2011.10.003. [PDB: 3rhu]
  • Bacik, John-Paul; Whitworth, Garrett E.; Stubbs, Keith A.; Vocadlo, David J.; Mark, Brian L. (2012). Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion. Chemistry & Biology 19(11) , 1471-1482. 10.1016/j.chembiol.2012.09.016. [PDB: 4gyj, 4gyk, 4gvg, 4gvf, 4gvh]
  • Baral, Pravas Kumar; Wieland, Barbara; Swayampakula, Mridula; Polymenidou, Magdalini; Rahman, Muhammad Hafiz; Kav, Nat N. V.; Aguzzi, Adriano; James, Michael N. G. (2012). Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta Crystallographica Section D Biological Crystallography 68(11) , 1501-1512. 10.1107/s0907444912037328. [PDB: 4dgi]
  • Burkinshaw, B. J.; Prehna, G.; Worrall, L. J.; Strynadka, N. C. J. (2012). Structure of Salmonella Effector Protein SopB N-terminal Domain in Complex with Host Rho GTPase Cdc42. Journal of Biological Chemistry 287(16) , 13348-13355. 10.1074/jbc.m111.331330. [PDB: 4did]
  • Calmettes, Charles; Alcantara, Joenel; Yu, Rong-Hua; Schryvers, Anthony B; Moraes, Trevor F (2012). The structural basis of transferrin sequestration by transferrin-binding protein B. Nature Structural & Molecular Biology 19(3) , 358-360. 10.1038/nsmb.2251.
  • Campbell, S. J.; Edwards, R. A.; Leung, C. C. Y.; Neculai, D.; Hodge, C. D.; Dhe-Paganon, S.; Glover, J. N. M. (2012). Molecular Insights into the Function of RING Finger (RNF)-containing Proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent Ubiquitylation. Journal of Biological Chemistry 287(28) , 23900-23910. 10.1074/jbc.m112.359653.
  • Cappadocia, L.; Parent, J.-S.; Zampini, E.; Lepage, E.; Sygusch, J.; Brisson, N. (2012). A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Research 40(1) , 258-269. 10.1093/nar/gkr740. [PDB: 3r9y]
  • Cherney, Maia M.; Zhang, Yanfei; James, Michael N.G.; Weiner, Joel H. (2012). Structure–activity characterization of sulfide:quinone oxidoreductase variants. Journal of Structural Biology 178(3) , 319-328. 10.1016/j.jsb.2012.04.007. [PDB: 3szf, 3sz0, 3szc, 3szw, 3sx6, 3t0k, 3syi, 3sy4]
  • Chong, Pek; Sebahar, Paul; Youngman, Michael; Garrido, Dulce; Zhang, Huichang; Stewart, Eugene L.; Nolte, Robert T.; Wang, Liping; Ferris, Robert G.; Edelstein, Mark; Weaver, Kurt; Mathis, Amanda; Peat, Andrew (2012). Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Journal of Medicinal Chemistry 55(23) , 10601-10609. 10.1021/jm301294g. [PDB: 2yni]
  • Cotelesage, Julien J. H.; Grochulski, Pawel; Pickering, Ingrid J.; George, Graham N.; Fodje, Michel N. (2012). X-ray absorption spectroscopy at a protein crystallography facility: the Canadian Light Source beamline 08B1-1. Journal of Synchrotron Radiation 19(6) , 887-891. 10.1107/s090904951204023x.
  • Epstein, L. F.; Chen, H.; Emkey, R.; Whittington, D. A. (2012). The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase. Journal of Biological Chemistry 287(44) , 37447-37457. 10.1074/jbc.m112.391425. [PDB: 4fnz]
  • Fieldhouse, R. J.; Jorgensen, R.; Lugo, M. R.; Merrill, A. R. (2012). The 1.8 A Cholix Toxin Crystal Structure in Complex with NAD+ and Evidence for a New Kinetic Model. Journal of Biological Chemistry 287(25) , 21176-21188. 10.1074/jbc.m111.337311. [PDB: 3q9o]
  • Fodje, Michel; Janzen, Kathryn; Berg, Russ; Black, Gillian; Labiuk, Shaunivan; Gorin, James; Grochulski, Pawel (2012). MxDC and MxLIVE : software for data acquisition, information management and remote access to macromolecular crystallography beamlines. Journal of Synchrotron Radiation 19(2) , 274-280. 10.1107/s0909049511056305.
  • Frank, Filipp; Hauver, Jesse; Sonenberg, Nahum; Nagar, Bhushan (2012). Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. The EMBO Journal 31(17) , 3588-3595. 10.1038/emboj.2012.204. [PDB: 4g0x]
  • Gomery, K.; Muller-Loennies, S.; Brooks, C. L.; Brade, L.; Kosma, P.; Di Padova, F.; Brade, H.; Evans, S. V. (2012). Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS. Proceedings of the National Academy of Sciences 109(51) , 20877-20882. 10.1073/pnas.1209253109. [PDB: 3v0w]
  • Grishin, A. M.; Ajamian, E.; Zhang, L.; Rouiller, I.; Bostina, M.; Cygler, M. (2012). Protein-Protein Interactions in the  -Oxidation Part of the Phenylacetate Utilization Pathway: CRYSTAL STRUCTURE OF THE PaaF-PaaG HYDRATASE-ISOMERASE COMPLEX. Journal of Biological Chemistry 287(45) , 37986-37996. 10.1074/jbc.m112.388231. [PDB: 4fzw]
  • Grochulski, Pawel; Fodje, Michel; Labiuk, Shaunivan; Gorin, James; Janzen, Kathryn; Berg, Russ (2012). Canadian macromolecular crystallography facility: a suite of fully automated beamlines. Journal of Structural and Functional Genomics 13(2) , 49-55. 10.1007/s10969-012-9123-9.
  • Hehemann, J.-H.; Kelly, A. G.; Pudlo, N. A.; Martens, E. C.; Boraston, A. B. (2012). Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes. Proceedings of the National Academy of Sciences 109(48) , 19786-19791. 10.1073/pnas.1211002109. [PDB: 4aw7]
  • Hehemann, J.-H.; Smyth, L.; Yadav, A.; Vocadlo, D. J.; Boraston, A. B. (2012). Analysis of Keystone Enzyme in Agar Hydrolysis Provides Insight into the Degradation (of a Polysaccharide from) Red Seaweeds. Journal of Biological Chemistry 287(17) , 13985-13995. 10.1074/jbc.m112.345645. [PDB: 4ak7]
  • Jha, Vikash; Chelikani, Prashen; Carpena, Xavi; Fita, Ignacio; Loewen, Peter C. (2012). Influence of main channel structure on H2O2 access to the heme cavity of catalase KatE of Escherichia coli. Archives of Biochemistry and Biophysics 526(1) , 54-59. 10.1016/j.abb.2012.06.010. [PDB: 4ens, 4enr, 4enp, 4enw, 4env, 4enu, 4ent]
  • Jha, Vikash; Donald, Lynda J.; Loewen, Peter C. (2012). Mutation of Phe413 to Tyr in catalase KatE from Escherichia coli leads to side chain damage and main chain cleavage. Archives of Biochemistry and Biophysics 525(2) , 207-214. 10.1016/j.abb.2011.11.022. [PDB: 3ttx, 3ttt, 3ttw, 3ttv]
  • Juang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles C.Y.; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Daniel Y.L.; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel (2012). OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function. Molecular Cell 45(3) , 384-397. 10.1016/j.molcel.2012.01.011. [PDB: 4ddg]
  • Kalynych, S.; Yao, D.; Magee, J.; Cygler, M. (2012). Structural Characterization of Closely Related O-antigen Lipopolysaccharide (LPS) Chain Length Regulators. Journal of Biological Chemistry 287(19) , 15696-15705. 10.1074/jbc.m112.354837. [PDB: 4e2l, 4e2h, 4e2c]
  • King, Dustin T.; Worrall, Liam J.; Gruninger, Robert; Strynadka, Natalie C. J. (2012). New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition. Journal of the American Chemical Society 134(28) , 11362-11365. 10.1021/ja303579d. [PDB: 4eyb, 4eyf, 4eyl, 4ey2, 4exy]
  • Kolappan, Subramaniapillai; Tracy, Erin N.; Bakaletz, Lauren O.; Munson, Robert S.; Craig, Lisa (2012). Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus. Acta Crystallographica Section F Structural Biology and Crystallization Communications 68(3) , 284-287. 10.1107/s1744309111043910.
  • Leisch, H.; Shi, R.; Grosse, S.; Morley, K.; Bergeron, H.; Cygler, M.; Iwaki, H.; Hasegawa, Y.; Lau, P. C. K. (2012). Cloning, Baeyer-Villiger Biooxidations, and Structures of the Camphor Pathway 2-Oxo- 3-4,5,5-Trimethylcyclopentenylacetyl-Coenzyme A Monooxygenase of Pseudomonas putida ATCC 17453. Applied and Environmental Microbiology 78(7) , 2200-2212. 10.1128/aem.07694-11. [PDB: 3up4, 3up5]
  • Leung, Kevin Ka Ki; Litchfield, David W.; Shilton, Brian H. (2012). Flavin adenine dinucleotide content of quinone reductase 2: Analysis and optimization for structure–function studies. Analytical Biochemistry 420(1) , 84-89. 10.1016/j.ab.2011.09.011.
  • Lin, Yih-Shyan; Park, Jaeok; De Schutter, Joris W.; Huang, Xian Fang; Berghuis, Albert M.; Sebag, Michael; Tsantrizos, Youla S. (2012). Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells. Journal of Medicinal Chemistry 55(7) , 3201-3215. 10.1021/jm201657x. [PDB: 4dem]
  • Liu, Xiaohu; Chen, Min; Lobo, Paolo; An, Jianghong; Grace Cheng, S.W.; Moradian, Annie; Morin, Gregg B.; Van Petegem, Filip; Jiang, Xiaoyan (2012). Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL + chronic myeloid leukemia cells to tyrosine kinase inhibitors. PROTEOMICS 12(13) , 2094-2106. 10.1002/pmic.201100553. [PDB: 4esr]
  • Loewen, Peter C.; Didychuk, Allison L.; Switala, Jacek; Perez-Luque, Rosa; Fita, Ignacio; Loewen, Michele C. (2012). Structure of Pisum sativum Rubisco with bound ribulose 1,5-bisphosphate. Acta Crystallographica Section F Structural Biology and Crystallization Communications 69(1) , 10-14. 10.1107/s1744309112047549. [PDB: 4mkv, 4hhh]
  • MacFarlane, Ainsley A.; Orriss, George; Okun, Natalie; Meier, Markus; Klonisch, Thomas; Khajehpour, Mazdak; Stetefeld, Jörg (2012). The Pentameric Channel of COMPcc in Complex with Different Fatty Acids. PLoS ONE 7(11) , e48130. 10.1371/journal.pone.0048130. [PDB: 3v2p, 3v2n, 3v2q]
  • Nam, Sung-Eun; Kim, Apollos C.; Paetzel, Mark (2012). Crystal Structure of Bacillus subtilis Signal Peptide Peptidase A. Journal of Molecular Biology 419(5) , 347-358. 10.1016/j.jmb.2012.03.020. [PDB: 3rst]
  • Norman, Mark H.; Andrews, Kristin L.; Bo, Yunxin Y.; Booker, Shon K.; Caenepeel, Sean; Cee, Victor J.; D’Angelo, Noel D.; Freeman, Daniel J.; Herberich, Bradley J.; Hong, Fang-Tsao; Jackson, Claire L. M.; Jiang, Jian; Lanman, Brian A.; Liu, Longbin; McCarter, John D.; Mullady, Erin L.; Nishimura, Nobuko; Pettus, Liping H.; Reed, Anthony B.; Miguel, Tisha San; Smith, Adrian L.; Stec, Markian M.; Tadesse, Seifu; Tasker, Andrew; Aidasani, Divesh; Zhu, Xiaochun; Subramanian, Raju; Tamayo, Nuria A.; Wang, Ling; Whittington, Douglas A.; Wu, Bin; Wu, Tian; Wurz, Ryan P.; Yang, Kevin; Zalameda, Leeanne; Zhang, Nancy; Hughes, Paul E. (2012). Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511. Journal of Medicinal Chemistry 55(17) , 7796-7816. 10.1021/jm300846z. [PDB: 4flh]
  • O'Sullivan, Valerie J.; Barrette-Ng, Isabelle; Hommema, Eric; Hermanson, Greg T.; Schofield, Mark; Wu, Sau-Ching; Honetschlaeger, Claudia; Ng, Kenneth K.-S.; Wong, Sui-Lam (2012). Development of a Tetrameric Streptavidin Mutein with Reversible Biotin Binding Capability: Engineering a Mobile Loop as an Exit Door for Biotin. PLoS ONE 7(4) , e35203. 10.1371/journal.pone.0035203.
  • Pfoh, R.; Li, A.; Chakrabarti, N.; Payandeh, J.; Pomes, R.; Pai, E. F. (2012). Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation. Proceedings of the National Academy of Sciences 109(46) , 18809-18814. 10.1073/pnas.1209018109. [PDB: 4eed, 4eeb]
  • Purohit, Meena K.; Poduch, Ewa; Wei, Lianhu William; Crandall, Ian Edward; To, Terrence; Kain, Kevin C.; Pai, Emil F.; Kotra, Lakshmi P. (2012). Novel Cytidine-Based Orotidine-5′-Monophosphate Decarboxylase Inhibitors with an Unusual Twist. Journal of Medicinal Chemistry 55(22) , 9988-9997. 10.1021/jm301176r. [PDB: 4hib]
  • Ratto, M. H.; Leduc, Y. A.; Valderrama, X. P.; van Straaten, K. E.; Delbaere, L. T. J.; Pierson, R. A.; Adams, G. P. (2012). The nerve of ovulation-inducing factor in semen. Proceedings of the National Academy of Sciences 109(37) , 15042-15047. 10.1073/pnas.1206273109. [PDB: 4efv]
  • Safaee, Nozhat; Kozlov, Guennadi; Noronha, Anne M.; Xie, Jingwei; Wilds, Christopher J.; Gehring, Kalle (2012). Interdomain Allostery Promotes Assembly of the Poly(A) mRNA Complex with PABP and eIF4G. Molecular Cell 48(3) , 375-386. 10.1016/j.molcel.2012.09.001. [PDB: 4f02]
  • Samborska, Bożena; Kimber, Matthew S. (2012). A Dodecameric CcmK2 Structure Suggests β-Carboxysomal Shell Facets Have a Double-Layered Organization. Structure 20(8) , 1353-1362. 10.1016/j.str.2012.05.013.
  • Sarhan, M. F.; Tung, C.-C.; Van Petegem, F.; Ahern, C. A. (2012). Crystallographic basis for calcium regulation of sodium channels. Proceedings of the National Academy of Sciences 109(9) , 3558-3563. 10.1073/pnas.1114748109. [PDB: 4djc]
  • Schroeder, Gretchen M.; Wei, Donna; Banfi, Patrizia; Cai, Zhen-Wei; Lippy, Jonathan; Menichincheri, Maria; Modugno, Michele; Naglich, Joseph; Penhallow, Becky; Perez, Heidi L.; Sack, John; Schmidt, Robert J.; Tebben, Andrew; Yan, Chunhong; Zhang, Liping; Galvani, Arturo; Lombardo, Louis J.; Borzilleri, Robert M. (2012). Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorganic & Medicinal Chemistry Letters 22(12) , 3951-3956. 10.1016/j.bmcl.2012.04.106. [PDB: 4ehr]
  • Shi, R.; Munger, C.; Kalan, L.; Sulea, T.; Wright, G. D.; Cygler, M. (2012). Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold. Proceedings of the National Academy of Sciences 109(29) , 11824-11829. 10.1073/pnas.1205377109.
  • Shniffer, A.; Visschedyk, D. D.; Ravulapalli, R.; Suarez, G.; Turgeon, Z. J.; Petrie, A. A.; Chopra, A. K.; Merrill, A. R. (2012). Characterization of an Actin-targeting ADP-ribosyltransferase from Aeromonas hydrophila. Journal of Biological Chemistry 287(44) , 37030-37041. 10.1074/jbc.m112.397612. [PDB: 4fml]
  • Siarheyeva, Alena; Senisterra, Guillermo; Allali-Hassani, Abdellah; Dong, Aiping; Dobrovetsky, Elena; Wasney, Gregory A.; Chau, Irene; Marcellus, Richard; Hajian, Taraneh; Liu, Feng; Korboukh, Ilia; Smil, David; Bolshan, Yuri; Min, Jinrong; Wu, Hong; Zeng, Hong; Loppnau, Peter; Poda, Gennadiy; Griffin, Carly; Aman, Ahmed; Brown, Peter J.; Jin, Jian; Al-awar, Rima; Arrowsmith, Cheryl H.; Schapira, Matthieu; Vedadi, Masoud (2012). An Allosteric Inhibitor of Protein Arginine Methyltransferase 3. Structure 20(8) , 1425-1435. 10.1016/j.str.2012.06.001. [PDB: 3smq]
  • Singh, R.; Grigg, J. C.; Armstrong, Z.; Murphy, M. E. P.; Eltis, L. D. (2012). Distal Heme Pocket Residues of B-type Dye-decolorizing Peroxidase: ARGININE BUT NOT ASPARTATE IS ESSENTIAL FOR PEROXIDASE ACTIVITY. Journal of Biological Chemistry 287(13) , 10623-10630. 10.1074/jbc.m111.332171. [PDB: 3ved, 3vee, 3vef, 3veg, 3vec]
  • Tonkin, Michelle L.; Crawford, Joanna; Lebrun, Maryse L.; Boulanger, Martin J. (2012). Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion. Protein Science 22(1) , 114-127. 10.1002/pro.2193. [PDB: 4apl]
  • Ukpabi, G.; Takayama, S.-i. J.; Mauk, A. G.; Murphy, M. E. P. (2012). Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling. Journal of Biological Chemistry 287(41) , 34179-34188. 10.1074/jbc.m112.393249. [PDB: 4fnh]
  • van Straaten, K. E.; Routier, F. H.; Sanders, D. A. R. (2012). Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus. Journal of Biological Chemistry 287(14) , 10780-10790. 10.1074/jbc.m111.322974. [PDB: 3ukh, 3ukk, 3ukl, 3uka, 3ukf, 3ukq, 3ukp]
  • van Straaten, Karin E.; Routier, Francoise H.; Sanders, David A. R. (2012). Towards the crystal structure elucidation of eukaryotic UDP-galactopyranose mutase. Acta Crystallographica Section F Structural Biology and Crystallization Communications 68(4) , 455-459. 10.1107/s1744309112006914.
  • Visschedyk, D.; Rochon, A.; Tempel, W.; Dimov, S.; Park, H.-W.; Merrill, A. R. (2012). Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus. Journal of Biological Chemistry 287(49) , 41089-41102. 10.1074/jbc.m112.412809. [PDB: 4gf1, 4fxq]
  • Wheatley, R. W.; Zheng, R. B.; Richards, M. R.; Lowary, T. L.; Ng, K. K. S. (2012). Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan. Journal of Biological Chemistry 287(33) , 28132-28143. 10.1074/jbc.m112.347484.
  • Wong, A. H. M.; Zhou, D.; Rini, J. M. (2012). The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. Journal of Biological Chemistry 287(44) , 36804-36813. 10.1074/jbc.m112.398842. [PDB: 4fyq, 4fys, 4fyr, 4fyt]
  • Xu, Yufei; Xu, Chao; Kato, Akiko; Tempel, Wolfram; Abreu, Jose Garcia; Bian, Chuanbing; Hu, Yeguang; Hu, Di; Zhao, Bin; Cerovina, Tanja; Diao, Jianbo; Wu, Feizhen; He, Housheng Hansen; Cui, Qingyan; Clark, Erin; Ma, Chun; Barbara, Andrew; Veenstra, Gert Jan C.; Xu, Guoliang; Kaiser, Ursula B.; Liu, X. Shirley; Sugrue, Stephen P.; He, Xi; Min, Jinrong; Kato, Yoichi; Shi, Yujiang Geno (2012). Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development. Cell 151(6) , 1200-1213. 10.1016/j.cell.2012.11.014. [PDB: 4hp1, 4hp3]
  • Yu, Angel C.Y.; Worrall, Liam J.; Strynadka, Natalie C.J. (2012). Structural Insight into the Bacterial Mucinase StcE Essential to Adhesion and Immune Evasion during Enterohemorrhagic E. coli Infection. Structure 20(4) , 707-717. 10.1016/j.str.2012.02.015. [PDB: 3ujz]
  • Yuchi, Zhiguang; Lau, Kelvin; Van Petegem, Filip (2012). Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain. Structure 20(7) , 1201-1211. 10.1016/j.str.2012.04.015. [PDB: 4erv, 4ert, 4etv]

2011 

  • Bacik, J.-P.; Whitworth, G. E.; Stubbs, K. A.; Yadav, A. K.; Martin, D. R.; Bailey-Elkin, B. A.; Vocadlo, D. J.; Mark, B. L. (2011). Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase. Journal of Biological Chemistry 286(14) , 12283-12291. 10.1074/jbc.m110.198317. [PDB: 3qbx, 3qbw]
  • Bains, Jasleen; Leon, Rafael; Temke, Kevin G.; Boulanger, Martin J. (2011). Elucidating the reaction mechanism of the benzoate oxidation pathway encoded aldehyde dehydrogenase from Burkholderia xenovorans LB400. Protein Science 20(6) , 1048-1059. 10.1002/pro.639. [PDB: 2y51, 2y52, 2y53, 2y5d]
  • Baral, Pravas Kumar; Wieland, Barbara; Swayampakula, Mridula; Polymenidou, Magdalini; Aguzzi, Adriano; Kav, Nat N. V.; James, Michael N. G. (2011). Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(10) , 1211-1213. 10.1107/s1744309111026273.
  • Bourhis, Eric; Wang, Weiru; Tam, Christine; Hwang, Jiyoung; Zhang, Yingnan; Spittler, Didier; Huang, Oscar W.; Gong, Yan; Estevez, Alberto; Zilberleyb, Inna; Rouge, Lionel; Chiu, Cecilia; Wu, Yan; Costa, Mike; Hannoush, Rami N.; Franke, Yvonne; Cochran, Andrea G. (2011). Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6. Structure 19(10) , 1433-1442. 10.1016/j.str.2011.07.005. [PDB: 3sov]
  • Calmettes, C.; Yu, R.-h.; Silva, L. P.; Curran, D.; Schriemer, D. C.; Schryvers, A. B.; Moraes, T. F. (2011). Structural Variations within the Transferrin Binding Site on Transferrin-binding Protein B, TbpB. Journal of Biological Chemistry 286(14) , 12683-12692. 10.1074/jbc.m110.206102. [PDB: 3pqs, 3pqu]
  • Cherney, Maia M.; Cherney, Leonid T.; Garen, Craig R.; James, Michael N.G. (2011). The Structures of Thermoplasma volcanium Phosphoribosyl Pyrophosphate Synthetase Bound to Ribose-5-Phosphate and ATP Analogs. Journal of Molecular Biology 413(4) , 844-856. 10.1016/j.jmb.2011.09.007. [PDB: 3mbi, 3nag, 3lrt, 3lpn]
  • Chung, I. Y. W.; Paetzel, M. (2011). Crystal Structure of a Viral Protease Intramolecular Acyl-enzyme Complex: INSIGHTS INTO cis-CLEAVAGE AT THE VP4/VP3 JUNCTION OF TELLINA BIRNAVIRUS. Journal of Biological Chemistry 286(14) , 12475-12482. 10.1074/jbc.m110.198812. [PDB: 3p06]
  • Coquelle, N.; Havali-Shahriari, Z.; Bernstein, N.; Green, R.; Glover, J. N. M. (2011). Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates. Proceedings of the National Academy of Sciences 108(52) , 21022-21027. 10.1073/pnas.1112036108. [PDB: 3u7e, 3u7f]
  • Coquelle, Nicolas; Green, Ruth; Glover, J. N. Mark (2011). Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition. Biochemistry 50(21) , 4579-4589. 10.1021/bi2003795. [PDB: 3pxe, 3pxd, 3pxa, 3pxb]
  • Dalrymple, Sean A.; Sheoran, Inder; Kaminskyj, Susan G. W.; Sanders, David A. R. (2011). Preliminary X-ray crystallographic studies of UDP-glucose-4-epimerase from Aspergillus nidulans. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(8) , 885-887. 10.1107/s1744309111020914.
  • Edwards, Thomas E.; Leibly, David J.; Bhandari, Janhavi; Statnekov, Jacob B.; Phan, Isabelle; Dieterich, Shellie H.; Abendroth, Jan; Staker, Bart L.; Van Voorhis, Wesley C.; Myler, Peter J.; Stewart, Lance J. (2011). Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(9) , 1032-1037. 10.1107/s1744309111004349. [PDB: 3k9w]
  • Ficko-Blean, Elizabeth; Stuart, Christopher P.; Boraston, Alisdair B. (2011). Structural analysis of CPF_2247, a novel α-amylase from Clostridium perfringens. Proteins Structure Function and Bioinformatics 79(10) , 2771-2777. 10.1002/prot.23116. [PDB: 3ren]
  • Gregg, K. J.; Zandberg, W. F.; Hehemann, J.-H.; Whitworth, G. E.; Deng, L.; Vocadlo, D. J.; Boraston, A. B. (2011). Analysis of a New Family of Widely Distributed Metal-independent  -Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans. Journal of Biological Chemistry 286(17) , 15586-15596. 10.1074/jbc.m111.223172. [PDB: 3qt9]
  • Grigg, Jason C.; Mao, Cherry X.; Murphy, Michael E.P. (2011). Iron-Coordinating Tyrosine Is a Key Determinant of NEAT Domain Heme Transfer. Journal of Molecular Biology 413(3) , 684-698. 10.1016/j.jmb.2011.08.047. [PDB: 3qzn, 3qzo, 3qzp]
  • Grishin, A. M.; Ajamian, E.; Tao, L.; Zhang, L.; Menard, R.; Cygler, M. (2011). Structural and Functional Studies of the Escherichia coli Phenylacetyl-CoA Monooxygenase Complex. Journal of Biological Chemistry 286(12) , 10735-10743. 10.1074/jbc.m110.194423. [PDB: 3pvr, 3pvt, 3pvy, 3pwq, 3pw1, 3pw8]
  • Grochulski, Pawel; Fodje, Michel N.; Gorin, James; Labiuk, Shaunivan L.; Berg, Russ (2011). Beamline 08ID-1, the prime beamline of the Canadian Macromolecular Crystallography Facility. Journal of Synchrotron Radiation 18(4) , 681-684. 10.1107/s0909049511019431.
  • Harikrishnan, Lalgudi S.; Kamau, Muthoni G.; Wan, Honghe; Inghrim, Jennifer A.; Zimmermann, Kurt; Sang, Xiaopeng; Mastalerz, Harold A.; Johnson, Walter L.; Zhang, Guifen; Lombardo, Louis J.; Poss, Michael A.; Trainor, George L.; Tokarski, John S.; Lorenzi, Matthew V.; You, Dan; Gottardis, Marco M.; Baldwin, Kathy F.; Lippy, Jonathan; Nirschl, David S.; Qiu, Ruhui; Miller, Arthur V.; Khan, Javed; Sack, John S.; Purandare, Ashok V. (2011). Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3. Bioorganic & Medicinal Chemistry Letters 21(5) , 1425-1428. 10.1016/j.bmcl.2011.01.022. [PDB: 3q32]
  • He, Y.; Ning, T.; Xie, T.; Qiu, Q.; Zhang, L.; Sun, Y.; Jiang, D.; Fu, K.; Yin, F.; Zhang, W.; Shen, L.; Wang, H.; Li, J.; Lin, Q.; Sun, Y.; Li, H.; Zhu, Y.; Yang, D. (2011). Large-scale production of functional human serum albumin from transgenic rice seeds. Proceedings of the National Academy of Sciences 108(47) , 19078-19083. 10.1073/pnas.1109736108. [PDB: 3sqj]
  • Herold, J. Martin; Wigle, Tim J.; Norris, Jacqueline L.; Lam, Robert; Korboukh, Victoria K.; Gao, Cen; Ingerman, Lindsey A.; Kireev, Dmitri B.; Senisterra, Guillermo; Vedadi, Masoud; Tripathy, Ashutosh; Brown, Peter J.; Arrowsmith, Cheryl H.; Jin, Jian; Janzen, William P.; Frye, Stephen V. (2011). Small-Molecule Ligands of Methyl-Lysine Binding Proteins. Journal of Medicinal Chemistry 54(7) , 2504-2511. 10.1021/jm200045v. [PDB: 3p8h]
  • Hewitt, Stephen N.; Choi, Ryan; Kelley, Angela; Crowther, Gregory J.; Napuli, Alberto J.; Van Voorhis, Wesley C. (2011). Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(9) , 1006-1009. 10.1107/s1744309111022159. [PDB: 3u40]
  • Higgins, Melanie A.; Ficko-Blean, Elizabeth; Meloncelli, Peter J.; Lowary, Todd L.; Boraston, Alisdair B. (2011). The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate-Antigen-Hydrolyzing Enzymes. Journal of Molecular Biology 411(5) , 1017-1036. 10.1016/j.jmb.2011.06.035. [PDB: 2ygm]
  • Hough, Michael A.; Antonyuk, Svetlana V.; Barbieri, Sonia; Rustage, Neil; McKay, Alison L.; Servid, Amy E.; Eady, Robert R.; Andrew, Colin R.; Hasnain, S. Samar (2011). Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket. Journal of Molecular Biology 405(2) , 395-409. 10.1016/j.jmb.2010.10.035. [PDB: 2xlw, 2xlo]
  • Jadhav, Pramodkumar; Schatte, Gabriele; Labiuk, Shaunivan; Burnett, Peta-Gaye; Li, Bonnie; Okinyo-Owiti, Denis; Reaney, Martin; Grochulski, Pawel; Fodje, Michel; Sammynaiken, Ramaswami (2011). Cyclolinopeptide K butanol disolvate monohydrate. Acta Crystallographica Section E Structure Reports Online 67(9) , o2360-o2361. 10.1107/s1600536811032363.
  • James, T. W.; Frias-Staheli, N.; Bacik, J.-P.; Levingston Macleod, J. M.; Khajehpour, M.; Garcia-Sastre, A.; Mark, B. L. (2011). Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. Proceedings of the National Academy of Sciences 108(6) , 2222-2227. 10.1073/pnas.1013388108. [PDB: 3pt2, 3pse]
  • Jha, Vikash; Louis, Sherif; Chelikani, Prashen; Carpena, Xavi; Donald, Lynda J.; Fita, Ignacio; Loewen, Peter C. (2011). Modulation of Heme Orientation and Binding by a Single Residue in Catalase HPII of Escherichia coli. Biochemistry 50(12) , 2101-2110. 10.1021/bi200027v. [PDB: 3pq8, 3pq2, 3pq3, 3pq6, 3pq7, 3pq4, 3pq5, 3p9r, 3p9s, 3p9p, 3p9q]
  • Kanjee, Usheer; Gutsche, Irina; Alexopoulos, Eftichia; Zhao, Boyu; El Bakkouri, Majida; Thibault, Guillaume; Liu, Kaiyin; Ramachandran, Shaliny; Snider, Jamie; Pai, Emil F; Houry, Walid A (2011). Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. The EMBO Journal 30(5) , 931-944. 10.1038/emboj.2011.5. [PDB: 3q16]
  • Kim, Kelly H.; Aulakh, Suraaj; Tan, Wendy; Paetzel, Mark (2011). Crystallographic analysis of the C-terminal domain of the Escherichia coli lipoprotein BamC. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(11) , 1350-1358. 10.1107/s174430911103363x. [PDB: 3sns]
  • Kim, Kelly H.; Paetzel, Mark (2011). Crystal Structure of Escherichia coli BamB, a Lipoprotein Component of the β-Barrel Assembly Machinery Complex. Journal of Molecular Biology 406(5) , 667-678. 10.1016/j.jmb.2010.12.020.
  • King, Dustin; Strynadka, Natalie (2011). Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance. Protein Science 20(9) , 1484-1491. 10.1002/pro.697. [PDB: 3spu]
  • Lee, H. J.; Lairson, L. L.; Rich, J. R.; Lameignere, E.; Wakarchuk, W. W.; Withers, S. G.; Strynadka, N. C. J. (2011). Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter jejuni. Journal of Biological Chemistry 286(41) , 35922-35932. 10.1074/jbc.m111.261172. [PDB: 2x61]
  • Lewis, Melissa; Meza-Avina, Maria Elena; Wei, Lianhu; Crandall, Ian E.; Bello, Angelica Mara; Poduch, Ewa; Liu, Yan; Paige, Christopher J.; Kain, Kevin C.; Pai, Emil F.; Kotra, Lakshmi P. (2011). Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5′-Monophosphate Decarboxylase. Journal of Medicinal Chemistry 54(8) , 2891-2901. 10.1021/jm101642g. [PDB: 3mo7]
  • Li, Alison Yueh; Lee, Jaeyong; Borek, Dominika; Otwinowski, Zbyszek; Tibbits, Glen F.; Paetzel, Mark (2011). Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation. Journal of Molecular Biology 413(3) , 699-711. 10.1016/j.jmb.2011.08.049. [PDB: 3rv5]
  • Lobo, Paolo A.; Kimlicka, Lynn; Tung, Ching-Chieh; Van Petegem, Filip (2011). The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by β Strand Switching. Structure 19(6) , 790-798. 10.1016/j.str.2011.03.016.
  • Niu, Chunying; Yin, Jiang; Cherney, Maia M.; James, Michael N. G. (2011). Expression, purification and preliminary crystallographic analysis of Rv2247, the β subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(12) , 1637-1640. 10.1107/s1744309111038413.
  • Petkun, Svetlana; Shi, Rong; Li, Yunge; Asinas, Abdalin; Munger, Christine; Zhang, Linhua; Waclawek, Mandy; Soboh, Basem; Sawers, R. Gary; Cygler, Miroslaw (2011). Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure 19(12) , 1773-1783. 10.1016/j.str.2011.09.023. [PDB: 3ttd, 3ttf, 3ttc, 3tsp, 3tsq, 3tsu]
  • Pluvinage, Benjamin; Higgins, Melanie A.; Abbott, D. Wade; Robb, Craig; Dalia, Ankur B.; Deng, Lehua; Weiser, Jeffrey N.; Parsons, Thomas B.; Fairbanks, Antony J.; Vocadlo, David J.; Boraston, Alisdair B. (2011). Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis. Structure 19(11) , 1603-1614. 10.1016/j.str.2011.08.011. [PDB: 2yla]
  • Qiu, Liyan; Dhe-Paganon, Sirano (2011). Oligomeric Structure of the MALT1 Tandem Ig-Like Domains. PLoS ONE 6(9) , e23220. 10.1371/journal.pone.0023220.
  • Quan, Shu; Koldewey, Philipp; Tapley, Tim; Kirsch, Nadine; Ruane, Karen M; Pfizenmaier, Jennifer; Shi, Rong; Hofmann, Stephan; Foit, Linda; Ren, Guoping; Jakob, Ursula; Xu, Zhaohui; Cygler, Miroslaw; Bardwell, James C A (2011). Genetic selection designed to stabilize proteins uncovers a chaperone called Spy. Nature Structural & Molecular Biology 18(3) , 262-269. 10.1038/nsmb.2016. [PDB: 3o39]
  • Rangarajan, Erumbi S.; Ruane, Karen M.; Proteau, Ariane; Schrag, Joseph D.; Valladares, Ricardo; Gonzalez, Claudio F.; Gilbert, Michel; Yakunin, Alexander F.; Cygler, Miroslaw (2011). Structural and enzymatic characterization of NanS (YjhS), a 9-O-Acetyl N-acetylneuraminic acid esterase from Escherichia coli O157:H7. Protein Science 20(7) , 1208-1219. 10.1002/pro.649. [PDB: 3pt5]
  • Roberts, Joseph N.; Singh, Rahul; Grigg, Jason C.; Murphy, Michael E. P.; Bugg, Timothy D. H.; Eltis, Lindsay D. (2011). Characterization of Dye-Decolorizing Peroxidases from Rhodococcus jostii RHA1. Biochemistry 50(23) , 5108-5119. 10.1021/bi200427h. [PDB: 3qnr]
  • Schatte, Gabriele; Labiuk, Shaunivan; Li, Bonnie; Burnett, Peta-Gaye; Reaney, Martin; Grochulski, Pawel; Fodje, Michel; Yang, Jian; Sammynaiken, Ramaswami (2011). Cyclolinopeptide B methanol trisolvate. Acta Crystallographica Section E Structure Reports Online 68(1) , o50-o51. 10.1107/s1600536811051488.
  • Shi, Kun; Houston, Douglas R.; Berghuis, Albert M. (2011). Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2′′-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases. Biochemistry 50(28) , 6237-6244. 10.1021/bi200747f. [PDB: 3sg8]
  • Shi, R.; McDonald, L.; Cui, Q.; Matte, A.; Cygler, M.; Ekiel, I. (2011). Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Proceedings of the National Academy of Sciences 108(4) , 1302-1307. 10.1073/pnas.1012596108. [PDB: 3pnq, 3pno, 3pnm]
  • Sidhu, Navdeep S.; Delbaere, Louis T. J.; Sheldrick, George M. (2011). Structure of a highly NADP + -specific isocitrate dehydrogenase. Acta Crystallographica Section D Biological Crystallography 67(10) , 856-869. 10.1107/s0907444911028575. [PDB: 3mbc]
  • Sun, Tianjun; Hayakawa, Koto; Fraser, Marie E. (2011). ADP–Mg 2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(10) , 1168-1172. 10.1107/s1744309111028363. [PDB: 3pff]
  • Thede, G. L.; Arthur, D. C.; Edwards, R. A.; Buelow, D. R.; Wong, J. L.; Raivio, T. L.; Glover, J. N. M. (2011). Structure of the Periplasmic Stress Response Protein CpxP. Journal of Bacteriology 193(9) , 2149-2157. 10.1128/jb.01296-10. [PDB: 3qzc]
  • Tonkin, M. L.; Roques, M.; Lamarque, M. H.; Pugniere, M.; Douguet, D.; Crawford, J.; Lebrun, M.; Boulanger, M. J. (2011). Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide. Science 333(6041) , 463-467. 10.1126/science.1204988. [PDB: 2y8s, 2y8t]
  • Watanabe, Nobuhiko; Clay, Matthew D.; van Belkum, Marco J.; Fan, Chenguang; Vederas, John C.; James, Michael N.G. (2011). The Structure of ll-Diaminopimelate Aminotransferase from Chlamydia trachomatis: Implications for Its Broad Substrate Specificity. Journal of Molecular Biology 411(3) , 649-660. 10.1016/j.jmb.2011.06.023. [PDB: 3asb]
  • Wong, J. J. W.; Lu, J.; Edwards, R. A.; Frost, L. S.; Glover, J. N. M. (2011). Structural basis of cooperative DNA recognition by the plasmid conjugation factor, TraM. Nucleic Acids Research 39(15) , 6775-6788. 10.1093/nar/gkr296.
  • Wu, Hong; Zeng, Hong; Lam, Robert; Tempel, Wolfram; Amaya, Maria F.; Xu, Chao; Dombrovski, Ludmila; Qiu, Wei; Wang, Yanming; Min, Jinrong (2011). Structural and Histone Binding Ability Characterizations of Human PWWP Domains. PLoS ONE 6(6) , e18919. 10.1371/journal.pone.0018919. [PDB: 3lyi, 3llr]
  • Zoraghi, R.; Worrall, L.; See, R. H.; Strangman, W.; Popplewell, W. L.; Gong, H.; Samaai, T.; Swayze, R. D.; Kaur, S.; Vuckovic, M.; Finlay, B. B.; Brunham, R. C.; McMaster, W. R.; Davies-Coleman, M. T.; Strynadka, N. C.; Andersen, R. J.; Reiner, N. E. (2011). Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities. Journal of Biological Chemistry 286(52) , 44716-44725. 10.1074/jbc.m111.289033. [PDB: 3t05, 3t07]

2010 

  • Abbott, D. W.; Gilbert, H. J.; Boraston, A. B. (2010). The Active Site of Oligogalacturonate Lyase Provides Unique Insights into Cytoplasmic Oligogalacturonate  -Elimination. Journal of Biological Chemistry 285(50) , 39029-39038. 10.1074/jbc.m110.153981. [PDB: 3pe7]
  • Adams-Cioaba, Melanie A.; Guo, Yahong; Bian, ChuanBing; Amaya, Maria F.; Lam, Robert; Wasney, Gregory A.; Vedadi, Masoud; Xu, Chao; Min, Jinrong (2010). Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2. PLoS ONE 5(11) , e13559. 10.1371/journal.pone.0013559. [PDB: 3o8v]
  • Caly, Delphine L.; O'Toole, Paul W.; Moore, Stanley A. (2010). The 2.2-Å Structure of the HP0958 Protein from Helicobacter pylori Reveals a Kinked Anti-Parallel Coiled-Coil Hairpin Domain and a Highly Conserved Zn-Ribbon Domain. Journal of Molecular Biology 403(3) , 405-419. 10.1016/j.jmb.2010.08.051. [PDB: 3na7]
  • Campbell, Stephen J.; Edwards, Ross A.; Glover, J.N. Mark (2010). Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1. Structure 18(2) , 167-176. 10.1016/j.str.2009.12.008. [PDB: 3k0k, 3k0h, 3k15, 3k16]
  • Cherney, Maia M.; Zhang, Yanfei; Solomonson, Matthew; Weiner, Joel H.; James, Michael N.G. (2010). Crystal Structure of Sulfide:Quinone Oxidoreductase from Acidithiobacillus ferrooxidans: Insights into Sulfidotrophic Respiration and Detoxification. Journal of Molecular Biology 398(2) , 292-305. 10.1016/j.jmb.2010.03.018. [PDB: 3t31]
  • Chung, Ivy Yeuk Wah; Paetzel, Mark (2010). Expression, purification and crystallization of VP4 protease from Tellina virus 1. Acta Crystallographica Section F Structural Biology and Crystallization Communications 67(1) , 157-160. 10.1107/s1744309110048803.
  • Cid, M.; Pedersen, H. L.; Kaneko, S.; Coutinho, P. M.; Henrissat, B.; Willats, W. G. T.; Boraston, A. B. (2010). Recognition of the Helical Structure of  -1,4-Galactan by a New Family of Carbohydrate-binding Modules. Journal of Biological Chemistry 285(46) , 35999-36009. 10.1074/jbc.m110.166330.
  • Dresen, C.; Lin, L. Y.- C.; D'Angelo, I.; Tocheva, E. I.; Strynadka, N.; Eltis, L. D. (2010). A Flavin-dependent Monooxygenase from Mycobacterium tuberculosis Involved in Cholesterol Catabolism. Journal of Biological Chemistry 285(29) , 22264-22275. 10.1074/jbc.m109.099028. [PDB: 3aff]
  • Gould, A. D.; Shilton, B. H. (2010). Studies of the Maltose Transport System Reveal a Mechanism for Coupling ATP Hydrolysis to Substrate Translocation without Direct Recognition of Substrate. Journal of Biological Chemistry 285(15) , 11290-11296. 10.1074/jbc.m109.089078. [PDB: 3kjt, 3hpi]
  • Grigg, J. C.; Cooper, J. D.; Cheung, J.; Heinrichs, D. E.; Murphy, M. E. P. (2010). The Staphylococcus aureus Siderophore Receptor HtsA Undergoes Localized Conformational Changes to Enclose Staphyloferrin A in an Arginine-rich Binding Pocket. Journal of Biological Chemistry 285(15) , 11162-11171. 10.1074/jbc.m109.097865. [PDB: 3li2]
  • Grishin, Andrey M.; Ajamian, Eunice; Zhang, Linhua; Cygler, Miroslaw (2010). Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex. Acta Crystallographica Section F Structural Biology and Crystallization Communications 66(9) , 1045-1049. 10.1107/s174430911002748x.
  • He, Xiao; Szewczyk, Paul; Karyakin, Andrey; Evin, Mariah; Hong, Wen-Xu; Zhang, Qinghai; Chang, Geoffrey (2010). Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature 467(7318) , 991-994. 10.1038/nature09408.
  • Kaustov, L.; Ouyang, H.; Amaya, M.; Lemak, A.; Nady, N.; Duan, S.; Wasney, G. A.; Li, Z.; Vedadi, M.; Schapira, M.; Min, J.; Arrowsmith, C. H. (2010). Recognition and Specificity Determinants of the Human Cbx Chromodomains. Journal of Biological Chemistry 286(1) , 521-529. 10.1074/jbc.m110.191411. [PDB: 3i91, 3h91]
  • Khan, M. Q.; Sweeting, B.; Mulligan, V. K.; Arslan, P. E.; Cashman, N. R.; Pai, E. F.; Chakrabartty, A. (2010). Prion disease susceptibility is affected by  -structure folding propensity and local side-chain interactions in PrP. Proceedings of the National Academy of Sciences 107(46) , 19808-19813. 10.1073/pnas.1005267107. [PDB: 3o79]
  • Leung, C. C. Y.; Gong, Z.; Chen, J.; Glover, J. N. M. (2010). Molecular Basis of BACH1/FANCJ Recognition by TopBP1 in DNA Replication Checkpoint Control. Journal of Biological Chemistry 286(6) , 4292-4301. 10.1074/jbc.m110.189555. [PDB: 3al2, 3al3]
  • Li, J. W.; Matias, E.; Chen, N.; Kim, C.-Y.; Wang, J.; Gorin, J.; He, F.; Thorpe, P.; Lu, Y.; Chen, W. F.; Grochulski, P.; Chen, X. B.; Zhang, W. J. (2010). Investigations of mechanical vibrations for beamlines at the Canadian Light Source. Journal of Synchrotron Radiation 18(2) , 109-116. 10.1107/s0909049510041075.
  • Lovering, Andrew L; Lin, Leo Y-C; Sewell, Edward W; Spreter, Thomas; Brown, Eric D; Strynadka, Natalie C J (2010). Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nature Structural & Molecular Biology 17(5) , 582-589. 10.1038/nsmb.1819. [PDB: 3l7l, 3l7m, 3l7j, 3l7k]
  • Malakhova, Margarita; D'Angelo, Igor; Kim, Hong-Gyum; Kurinov, Igor; Bode, Ann M.; Dong, Zigang (2010). The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1. Journal of Molecular Biology 399(1) , 41-52. 10.1016/j.jmb.2010.03.064.
  • Meza-Avina, Maria Elena; Wei, Lianhu; Liu, Yan; Poduch, Ewa; Bello, Angelica M.; Mishra, Ram K.; Pai, Emil F.; Kotra, Lakshmi P. (2010). Structural determinants for the inhibitory ligands of orotidine-5′-monophosphate decarboxylase. Bioorganic & Medicinal Chemistry 18(11) , 4032-4041. 10.1016/j.bmc.2010.04.017. [PDB: 3mi2]
  • Moore, S. A.; Ferhatoglu, Y.; Jia, Y.; Al-Jiab, R. A.; Scott, M. J. (2010). Structural and Biochemical Studies on the Chromo-barrel Domain of Male Specific Lethal 3 (MSL3) Reveal a Binding Preference for Mono- or Dimethyllysine 20 on Histone H4. Journal of Biological Chemistry 285(52) , 40879-40890. 10.1074/jbc.m110.134312.
  • Moore, S. A.; Jia, Y. (2010). Structure of the Cytoplasmic Domain of the Flagellar Secretion Apparatus Component FlhA from Helicobacter pylori. Journal of Biological Chemistry 285(27) , 21060-21069. 10.1074/jbc.m110.119412. [PDB: 3myd]
  • Partha, Sarathy Karunan; Sadeghi-Khomami, Ali; Slowski, Kathryn; Kotake, Toshihisa; Thomas, Neil R.; Jakeman, David L.; Sanders, David A.R. (2010). Chemoenzymatic Synthesis, Inhibition Studies, and X-ray Crystallographic Analysis of the Phosphono Analog of UDP-Galp as an Inhibitor and Mechanistic Probe for UDP-Galactopyranose Mutase. Journal of Molecular Biology 403(4) , 578-590. 10.1016/j.jmb.2010.08.053. [PDB: 3mj4]
  • Pena, K. L.; Castel, S. E.; de Araujo, C.; Espie, G. S.; Kimber, M. S. (2010). Structural basis of the oxidative activation of the carboxysomal  -carbonic anhydrase, CcmM. Proceedings of the National Academy of Sciences 107(6) , 2455-2460. 10.1073/pnas.0910866107.
  • Protsko, Carla; Vieille, Claire; Laivenieks, Maris; Prasad, Lata; Sanders, David A. R.; Delbaere, Louis T. J. (2010). Crystallization and preliminary X-ray diffraction analysis of the Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase I86A mutant. Acta Crystallographica Section F Structural Biology and Crystallization Communications 66(7) , 831-833. 10.1107/s1744309110018981.
  • Reniere, Michelle L.; Ukpabi, Georgia N.; Harry, S. Reese; Stec, Donald F.; Krull, Robert; Wright, David W.; Bachmann, Brian O.; Murphy, Michael E.; Skaar, Eric P. (2010). The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Molecular Microbiology 75(6) , 1529-1538. 10.1111/j.1365-2958.2010.07076.x. [PDB: 3lgm, 3lgn]
  • Shi, Rong; Munger, Christine; Asinas, Abdalin; Benoit, Stéphane L.; Miller, Erica; Matte, Allan; Maier, Robert J.; Cygler, Miroslaw (2010). Crystal Structures of Apo and Metal-Bound Forms of the UreE Protein from Helicobacter pylori : Role of Multiple Metal Binding Sites,. Biochemistry 49(33) , 7080-7088. 10.1021/bi100372h. [PDB: 3nxz, 3ny0]
  • Shi, Rong; Proteau, Ariane; Villarroya, Magda; Moukadiri, Ismaïl; Zhang, Linhua; Trempe, Jean-François; Matte, Allan; Armengod, M. Eugenia; Cygler, Miroslaw (2010). Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions. PLoS Biology 8(4) , e1000354. 10.1371/journal.pbio.1000354. [PDB: 3lvl]
  • Sun, T.; Hayakawa, K.; Bateman, K. S.; Fraser, M. E. (2010). Identification of the Citrate-binding Site of Human ATP-Citrate Lyase Using X-ray Crystallography. Journal of Biological Chemistry 285(35) , 27418-27428. 10.1074/jbc.m109.078667. [PDB: 3mwd]
  • Tung, Ching-Chieh; Lobo, Paolo A.; Kimlicka, Lynn; Van Petegem, Filip (2010). The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature 468(7323) , 585-588. 10.1038/nature09471. [PDB: 2xoa]
  • Turgeon, Z.; Jorgensen, R.; Visschedyk, D.; Edwards, P. R.; Legree, S.; McGregor, C.; Fieldhouse, R. J.; Mangroo, D.; Schapira, M.; Merrill, A. R. (2010). Newly Discovered and Characterized Antivirulence Compounds Inhibit Bacterial Mono-ADP-Ribosyltransferase Toxins. Antimicrobial Agents and Chemotherapy 55(3) , 983-991. 10.1128/aac.01164-10.
  • van Straaten, Karin E.; Zheng, Hongyan; Palmer, David R. J.; Sanders, David A. R. (2010). Structural investigation of myo -inositol dehydrogenase from Bacillus subtilis : implications for catalytic mechanism and inositol dehydrogenase subfamily classification. Biochemical Journal 432(2) , 237-247. 10.1042/bj20101079. [PDB: 3mz0, 3ntr, 3ntq, 3nto, 3nt5, 3nt4, 3nt2]
  • Wang, W.; Mazurkewich, S.; Kimber, M. S.; Seah, S. Y. K. (2010). Structural and Kinetic Characterization of 4-Hydroxy-4-methyl-2-oxoglutarate/4-Carboxy-4-hydroxy-2-oxoadipate Aldolase, a Protocatechuate Degradation Enzyme Evolutionarily Convergent with the HpaI and DmpG Pyruvate Aldolases. Journal of Biological Chemistry 285(47) , 36608-36615. 10.1074/jbc.m110.159509. [PDB: 3noj]
  • Wernimont, Amy K.; Amani, Merhnaz; Qiu, Wei; Pizarro, Juan C.; Artz, Jennifer D.; Lin, Yu-Hui; Lew, Jocelyn; Hutchinson, Ashley; Hui, Raymond (2010). Structures of parasitic CDPK domains point to a common mechanism of activation. Proteins Structure Function and Bioinformatics 79(3) , 803-820. 10.1002/prot.22919. [PDB: 3k21]
  • Wiseman, B.; Carpena, X.; Feliz, M.; Donald, L. J.; Pons, M.; Fita, I.; Loewen, P. C. (2010). Isonicotinic Acid Hydrazide Conversion to Isonicotinyl-NAD by Catalase-peroxidases. Journal of Biological Chemistry 285(34) , 26662-26673. 10.1074/jbc.m110.139428. [PDB: 3n3n, 3n3r, 3n3s, 3n3p, 3n3q, 3n3o, 5sxq, 5sxr, 5sxs, 5sxt, 5sxw, 5sxx]
  • Worrall, Liam J.; Vuckovic, Marija; Strynadka, Natalie C. J. (2010). Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Science 19(5) , 1091-1096. 10.1002/pro.382. [PDB: 2x49]
  • Xu, C.; Bian, C.; Yang, W.; Galka, M.; Ouyang, H.; Chen, C.; Qiu, W.; Liu, H.; Jones, A. E.; MacKenzie, F.; Pan, P.; Li, S. S.-C.; Wang, H.; Min, J. (2010). Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proceedings of the National Academy of Sciences 107(45) , 19266-19271. 10.1073/pnas.1008937107.

2009 

  • Beasley, Federico C.; Vinés, Enrique D.; Grigg, Jason C.; Zheng, Qin; Liu, Suya; Lajoie, Gilles A.; Murphy, Michael E. P.; Heinrichs, David E. (2009). Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureus. Molecular Microbiology 72(4) , 947-963. 10.1111/j.1365-2958.2009.06698.x. [PDB: 3eiw]
  • Bello, Angelica M.; Konforte, Danijela; Poduch, Ewa; Furlonger, Caren; Wei, Lianhu; Liu, Yan; Lewis, Melissa; Pai, Emil F.; Paige, Christopher J.; Kotra, Lakshmi P. (2009). Structure−Activity Relationships of Orotidine-5′-Monophosphate Decarboxylase Inhibitors as Anticancer Agents. Journal of Medicinal Chemistry 52(6) , 1648-1658. 10.1021/jm801224t. [PDB: 3g3m]
  • Capyk, J. K.; D'Angelo, I.; Strynadka, N. C.; Eltis, L. D. (2009). Characterization of 3-Ketosteroid 9 -Hydroxylase, a Rieske Oxygenase in the Cholesterol Degradation Pathway of Mycobacterium tuberculosis. Journal of Biological Chemistry 284(15) , 9937-9946. 10.1074/jbc.m900719200. [PDB: 2zyl]
  • Cheung, Tsz Ying Sylvia; Fairchild, Michael J.; Zarivach, Raz; Tanentzapf, Guy; Van Petegem, Filip (2009). Crystal Structure of the Talin Integrin Binding Domain 2. Journal of Molecular Biology 387(4) , 787-793. 10.1016/j.jmb.2009.01.053. [PDB: 3fyq]
  • Eble, J. A.; Niland, S.; Bracht, T.; Mormann, M.; Peter-Katalinic, J.; Pohlentz, G.; Stetefeld, J. (2009). The  2 1 integrin-specific antagonist rhodocetin is a cruciform, heterotetrameric molecule. The FASEB Journal 23(9) , 2917-2927. 10.1096/fj.08-126763.
  • Higgins, M. A.; Whitworth, G. E.; El Warry, N.; Randriantsoa, M.; Samain, E.; Burke, R. D.; Vocadlo, D. J.; Boraston, A. B. (2009). Differential Recognition and Hydrolysis of Host Carbohydrate Antigens by Streptococcus pneumoniae Family 98 Glycoside Hydrolases. Journal of Biological Chemistry 284(38) , 26161-26173. 10.1074/jbc.m109.024067.
  • Karunan Partha, Sarathy; Bonderoff, Sara A.; van Straaten, Karin E.; Sanders, David A. R. (2009). Expression, purification and preliminary X-ray crystallographic analysis of UDP-galactopyranose mutase from Deinococcus radiodurans. Acta Crystallographica Section F Structural Biology and Crystallization Communications 65(8) , 843-845. 10.1107/s1744309109027754.
  • Karunan Partha, Sarathy; van Straaten, Karin E.; Sanders, David A.R. (2009). Structural Basis of Substrate Binding to UDP-galactopyranose Mutase: Crystal Structures in the Reduced and Oxidized State Complexed with UDP-galactopyranose and UDP. Journal of Molecular Biology 394(5) , 864-877. 10.1016/j.jmb.2009.10.013. [PDB: 3he3, 3hdq, 3hdy]
  • Lee, H. J.; Rakic, B.; Gilbert, M.; Wakarchuk, W. W.; Withers, S. G.; Strynadka, N. C. J. (2009). Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase OatWY from Neisseria meningitidis. Journal of Biological Chemistry 284(36) , 24501-24511. 10.1074/jbc.m109.006049. [PDB: 2wlg]
  • Leung, Charles Chung Yun; Kellogg, Elizabeth; Kuhnert, Anja; Hänel, Frank; Baker, David; Glover, J.N. Mark (2009). Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1. Protein Science , NA-NA. 10.1002/pro.290. [PDB: 3jve]
  • Li, Yang; He, Yujiong; Luo, Yu (2009). Conservation of a conformational switch in RadA recombinase from Methanococcus maripaludis. Acta Crystallographica Section D Biological Crystallography 65(6) , 602-610. 10.1107/s0907444909011871. [PDB: 3ew9, 3ewa, 3etl]
  • Li, Yang; He, Yujiong; Luo, Yu (2009). Crystal Structure of an Archaeal Rad51 Homologue in Complex with a Metatungstate Inhibitor. Biochemistry 48(29) , 6805-6810. 10.1021/bi900832t. [PDB: 3fyh]
  • Liu, Lili; O'Grady, Christopher; Dalrymple, Sean A.; Prasad, Lata; Dmitriev, Oleg Y.; Delbaere, Louis T. J. (2009). Crystallization and preliminary X-ray studies of the N-domain of the Wilson disease associated protein. Acta Crystallographica Section F Structural Biology and Crystallization Communications 65(6) , 621-624. 10.1107/s1744309109017023.
  • Lobo, Paolo Antonio; Van Petegem, Filip (2009). Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations. Structure 17(11) , 1505-1514. 10.1016/j.str.2009.08.016. [PDB: 3ila, 3im7, 3im6, 3im5]
  • McFarlane, Ainsley A.; Stetefeld, Jörg (2009). An interdomain disulfide bridge links the NtA and first FS domain in agrin. Protein Science 18(12) , 2421-2428. 10.1002/pro.276. [PDB: 3i70]
  • Moraes, Trevor F.; Yu, Rong-hua; Strynadka, Natalie C.J.; Schryvers, Anthony B. (2009). Insights into the Bacterial Transferrin Receptor: The Structure of Transferrin-Binding Protein B from Actinobacillus pleuropneumoniae. Molecular Cell 35(4) , 523-533. 10.1016/j.molcel.2009.06.029. [PDB: 3hoe, 3hol]
  • Orriss, G. L.; Patel, T. R.; Sorensen, J.; Stetefeld, J. (2009). Absence of a catalytic water confers resistance to the neurotoxin gabaculine. The FASEB Journal 24(2) , 404-414. 10.1096/fj.09-138297.
  • Osman, Khan Tanjid; Du, Liqin; He, Yujiong; Luo, Yu (2009). Crystal Structure of Bacillus cereus d-Alanyl Carrier Protein Ligase (DltA) in Complex with ATP. Journal of Molecular Biology 388(2) , 345-355. 10.1016/j.jmb.2009.03.040. [PDB: 3fcc]
  • Rao, Francesco V; Rich, Jamie R; Rakić, Bojana; Buddai, Sai; Schwartz, Marc F; Johnson, Karl; Bowe, Caryn; Wakarchuk, Warren W; DeFrees, Shawn; Withers, Stephen G; Strynadka, Natalie C J (2009). Structural insight into mammalian sialyltransferases. Nature Structural & Molecular Biology 16(11) , 1186-1188. 10.1038/nsmb.1685. [PDB: 2wnf]
  • Turgeon, Zachari; White, Dawn; Jørgensen, René; Visschedyk, Danielle; Fieldhouse, Robert J.; Mangroo, Dev; Merrill, A. Rod (2009). Yeast as a tool for characterizing mono-ADP-ribosyltransferase toxins. FEMS Microbiology Letters 300(1) , 97-106. 10.1111/j.1574-6968.2009.01777.x. [PDB: 3ess]
  • van Straaten, K. E.; Langill, D. M.; Palmer, D. R. J.; Sanders, D. A. R. (2009). Purification, crystallization and preliminary X-ray analysis of NtdA, a putative pyridoxal phosphate-dependent aminotransferase from Bacillus subtilis. Acta Crystallographica Section F Structural Biology and Crystallization Communications 65(4) , 426-429. 10.1107/s1744309109009038.
  • Zamyatkin, Dmitry F.; Parra, Francisco; Machín, Ángeles; Grochulski, Pawel; Ng, Kenneth K.-S. (2009). Binding of 2′-Amino-2′-Deoxycytidine-5′-Triphosphate to Norovirus Polymerase Induces Rearrangement of the Active Site. Journal of Molecular Biology 390(1) , 10-16. 10.1016/j.jmb.2009.04.069. [PDB: 3h5x, 3h5y]

2008 

  • Bello, Angelica M.; Poduch, Ewa; Liu, Yan; Wei, Lianhu; Crandall, Ian; Wang, Xiaoyang; Dyanand, Christopher; Kain, Kevin C.; Pai, Emil F.; Kotra, Lakshmi P. (2008). Structure–Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase †. Journal of Medicinal Chemistry 51(3) , 439-448. 10.1021/jm7010673. [PDB: 3bar]
  • Jørgensen, René; Wang, Yolanda; Visschedyk, Danielle; Merrill, A Rod (2008). The nature and character of the transition state for the ADP-ribosyltransferase reaction. EMBO Reports 9(8) , 802-809. 10.1038/embor.2008.90. [PDB: 2zit]
  • Marchetti, Adrian; Parker, Micaela S.; Moccia, Lauren P.; Lin, Ellen O.; Arrieta, Angele L.; Ribalet, Francois; Murphy, Michael E. P.; Maldonado, Maria T.; Armbrust, E. Virginia (2008). Ferritin is used for iron storage in bloom-forming marine pennate diatoms. Nature 457(7228) , 467-470. 10.1038/nature07539.
  • Phenix, Christopher P.; Nienaber, Kurt; Tam, Pui Hang; Delbaere, Louis T. J.; Palmer , David R. J. (2008). Structural, Functional and Calorimetric Investigation of MosA, a Dihydrodipicolinate Synthase from Sinorhizobium meliloti L5–30, does not Support Involvement in Rhizopine Biosynthesis. ChemBioChem 9(10) , 1591-1602. 10.1002/cbic.200700569. [PDB: 2vc6]
  • Sun, Wanpeng; Geyer, C. Ronald; Yang, Jian (2008). Cloning, Expression, Purification and Crystallization of the PR Domain of Human Retinoblastoma Protein-Binding Zinc Finger Protein 1 (RIZ1). International Journal of Molecular Sciences 9(6) , 943-950. 10.3390/ijms9060943.
  • Van Straaten, K. E.; Hoffort, A.; Palmer, D. R. J.; Sanders, D. A. R. (2008). Purification, crystallization and preliminary X-ray analysis of inositol dehydrogenase (IDH) from Bacillus subtilis. Acta Crystallographica Section F Structural Biology and Crystallization Communications 64(2) , 98-101. 10.1107/s1744309108000328.
  • Yin, Jiang; Garen, Craig R.; Cherney, Maia M.; Cherney, Leonid T.; James, Michael N. G. (2008). Expression, purification and preliminary crystallographic analysis of N -acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis. Acta Crystallographica Section F Structural Biology and Crystallization Communications 64(9) , 805-808. 10.1107/s1744309108024500.
  • Zamyatkin, D. F.; Parra, F.; Alonso, J. M. M.; Harki, D. A.; Peterson, B. R.; Grochulski, P.; Ng, K. K.-S. (2008). Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase. Journal of Biological Chemistry 283(12) , 7705-7712. 10.1074/jbc.m709563200. [PDB: 3bsn]

2007 

  • Duffy, Alan; Fodje, Michel; Berg, Russ; Grochulski, Pawel (2007). Canadian Macromolecular Crystallography Facility (CMCF) 08ID-1 status update. Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 582(1) , 82-83. 10.1016/j.nima.2007.08.066.
  • Grochulski, P.; Fodje, M.N.; Delbaere, L.T.J. (2007). CMCF 08ID-1 Beamline at the Canadian Light Source. In Acta Crystallographica Section A Foundations of Crystallography. International Union of Crystallography. , 245.
  • Mizuno, Y.; Moorhead, G. B. G.; Ng, K. K.-S. (2007). Structural Basis for the Regulation of N-Acetylglutamate Kinase by PII in Arabidopsis thaliana. Journal of Biological Chemistry 282(49) , 35733-35740. 10.1074/jbc.m707127200. [PDB: 2rd5]
  • Puttick, Jennifer; Vieille, Claire; Song, Seung H.; Fodje, Michel N.; Grochulski, Pawel; Delbaere, Louis T. J. (2007). Crystallization, preliminary X-ray diffraction and structure analysis of Thermotoga maritima mannitol dehydrogenase. Acta Crystallographica Section F Structural Biology and Crystallization Communications 63(4) , 350-352. 10.1107/s1744309107013097.

2006 

  • Qian, X.; He, Y.; Ma, X.; Fodje, M. N.; Grochulski, P.; Luo, Y. (2006). Calcium Stiffens Archaeal Rad51 Recombinase from Methanococcus voltae for Homologous Recombination. Journal of Biological Chemistry 281(51) , 39380-39387. 10.1074/jbc.m607785200. [PDB: 2i1q]

2004 

  • Prasad, Lata; Leduc, Yvonne; Hayakawa, Koto; Delbaere, Louis T. J. (2004). The structure of a universally employed enzyme: V8 protease from Staphylococcus aureus. Acta Crystallographica Section D Biological Crystallography 60(2) , 256-259. 10.1107/s090744490302599x. [PDB: 2o8l]