How cells overcome some of the toxic effects of benzopyrene...

July 27, 2018

Benzo[a]pyrene (BP) is a frequently-encountered carcinogen that generates a bulky DNA adduct. DNA polymerase kappa is the only known polymerase that can bypass the adduct accurately and protect cells from genotoxic effects. In this Mail-In project, the authors compare binding of normal DNA with BP-adducted DNA to unravel the unique mechanism for accurate replication. PDB ID 4U7C.