Canadian Macromolecular Crystallography Facility

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The Immune Response

How the immune system responds to bacterial infections...

Proc. Natl. Acad. Sci. USA 115, E896

Cell Signaling

Novel therapeutic targets for cardiac disease and cancer...

Nat. Chem. Biol. 13, 757

Viral Attack Strategies

Exploring how coronavirus adapts to new situations...

Nature Commun. 8, 1735

Broad-Spectrum Antibiotic Resistance

How bacteria can inactivate certain classes of antibiotics...

Structure 25, 750

DNA Damage Repair

How cells overcome some of the toxic effects of benzopyrene...

Nucleic Acids Res. 44, 4957

CMCF is an umbrella facility which operates two beamlines, 08ID-1 and 08B1-1, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.

List of Publications »

  • Bryan, Marian C.; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng et al. (2019). Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitor .... Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.9b00439. [PDB: 6o9d]
  • Mothersole, Robert G.; MacDonald, Marta; Kolesnikov, Maxim; Murphy, Michael E. P.; Wolthers, Kirsten R. et al. (2019). Structural insight into the high reduction potentials observed for .... Protein Science . 10.1002/pro.3661. [PDB: 6ohk]
  • Tamura, Kazune; Foley, Matthew H.; Gardill, Bernd R.; Dejean, Guillaume; Schnizlein, Matthew et al. (2019). Surface glycan-binding proteins are essential for cereal beta-glucan u .... Cellular and Molecular Life Sciences . 10.1007/s00018-019-03115-3. [PDB: 6e9b]