Canadian Macromolecular Crystallography Facility

Spring Maintenance

Advancing key upgrade objectives including higher throughput on CMCF-BM…

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Calling All Uni-Pucks!

Your help is needed - CMCF is running out of loaner Uni-Pucks…

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The Immune Response

How the immune system responds to bacterial infections...

Proc. Natl. Acad. Sci. USA 115, E896

Cell Signaling

Novel therapeutic targets for cardiac disease and cancer...

Nat. Chem. Biol. 13, 757

Viral Attack Strategies

Exploring how coronavirus adapts to new situations...

Nature Commun. 8, 1735

Broad-Spectrum Antibiotic Resistance

How bacteria can inactivate certain classes of antibiotics...

Structure 25, 750

DNA Damage Repair

How cells overcome some of the toxic effects of benzopyrene...

Nucleic Acids Res. 44, 4957

CMCF is an umbrella facility which operates two beamlines, 08ID-1 and 08B1-1, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.

List of Publications »

  • Li, Tang; Stephen, Preyesh; Zhu, Dao‐Wei; Shi, Rong; Lin, Sheng‐Xiang et al. (2019). Crystal structures of human 17β‐hydroxysteroid dehydrogenase type 1 co .... FEBS Journal . 10.1111/febs.14784. [PDB: 6mne]
  • Zhang, Birong; Kiefer, James R.; Blake, Robert A.; Chang, Jae H.; Hartman, Steven et al. (2019). Unexpected equivalent potency of a constrained chromene enantiomeric p .... Bioorganic and Medicinal Chemistry Letters 29(7) . 10.1016/j.bmcl.2019.01.036. [PDB: 6dfn]
  • Simonetta, Kyle R.; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E.; Padovani, Chris et al. (2019). Prospective discovery of small molecule enhancers of an E3 ligase-subs .... Nature Communications 10(1) , 1402. 10.1038/s41467-019-09358-9. [PDB: 6m91, 6m92, 6m93, 6m94]