Canadian Macromolecular Crystallography Facility

New CLS User Portal

A new portal with common login for training, proposal submissions and beamtime requests...

CLS User Portal

Updated Data Collection Interface!

Featuring improved crystal centering, automation & collection options plus many new features for a more efficient data collection experience...

MxDC Highlights

ISARA Sample Changer Commissioned

New CMCF-ID IRELEC ISARA sample changer used for the first time...

Samples & Automounters

MxLIVE Update

Simple, secure & streamlined sample tracking and data management...

MxLIVE User Guide Page

1000 Structures & 500 Publications!

Celebrating two milestones reached by scientists who conducted their research at the CMCF

Full CLS News Story

Tackling Autoimmune Diseases

Researchers combine CMCF-BM, CMCF-ID, SAXS & electron microscopy data to discover B-cell CD22 interaction details critical to a healthy immune response...

Nature Commun. 8, 764


CMCF is an umbrella facility which operates two beamlines, 08ID-1 and 08B1-1, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.


  • Beamline 08ID-1 Status:  Normal Operations
  • Beamline 08B1-1 Status:  Normal Operations

List of Publications »

  • Mallette, Evan; Kimber, Matthew S. (2018). Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase f .... Biochemistry . 10.1021/acs.biochem.8b00464.
  • Stöppler, Daniel; Macpherson, Alex; Smith-Penzel, Susanne; Basse, Nicolas; Lecomte, Fabien et al. (2018). Insight into small molecule binding to the neonatal Fc receptor by X-r .... PLoS Biology 16(5) , e2006192. 10.1371/journal.pbio.2006192.
  • Gorelik, Alexei; Randriamihaja, Antsa; Illes, Katalin; Nagar, Bhushan (2018). Structural basis for nucleotide recognition by the ectoenzyme CD203c. FEBS Journal . 10.1111/febs.14489.