Canadian Macromolecular Crystallography Facility

New CLS User Portal

A new portal with common login for training, proposal submissions and beamtime requests...

CLS User Portal

Updated Data Collection Interface!

Featuring improved crystal centering, automation & collection options plus many new features for a more efficient data collection experience...

MxDC Highlights

ISARA Sample Changer Commissioned

New CMCF-ID IRELEC ISARA sample changer used for the first time...

Samples & Automounters

MxLIVE Update

Simple, secure & streamlined sample tracking and data management...

MxLIVE User Guide Page

1000 Structures & 500 Publications!

Celebrating two milestones reached by scientists who conducted their research at the CMCF

Full CLS News Story

Tackling Autoimmune Diseases

Researchers combine CMCF-BM, CMCF-ID, SAXS & electron microscopy data to discover B-cell CD22 interaction details critical to a healthy immune response...

Nature Commun. 8, 764


CMCF is an umbrella facility which operates two beamlines, 08ID-1 and 08B1-1, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.


  • Beamline 08ID-1 Status:  CLS Facility Repairs
  • Beamline 08B1-1 Status:  CLS Facility Repairs

List of Publications »

  • Imkeller; Katharina; Scally; Stephen W.; Bosch et al. (2018). Antihomotypic affinity maturation improves human B cell responses agai .... Science 360(6395) , 1358-1362. 10.1126/science.aar5304. [PDB: 6d11, 6d01]
  • Qiu; Luping; Levine; Kymberly; Gajiwala et al. (2018). Small molecule inhibitors reveal PTK6 kinase is not an oncogenic drive .... PLoS ONE 13(6) , e0198374. 10.1371/journal.pone.0198374. [PDB: 6cz2, 6cz3]
  • Mallette; Evan; Kimber; Matthew S. (2018). Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase f .... Biochemistry . 10.1021/acs.biochem.8b00464. [PDB: 6ci9, 6ci8]