Canadian Macromolecular Crystallography Facility

New CLS User Portal

A new portal with common login for training, proposal submissions and beamtime requests...

CLS User Portal

Updated Data Collection Interface!

Featuring improved crystal centering, automation & collection options plus many new features for a more efficient data collection experience...

MxDC Highlights

ISARA Sample Changer Commissioned

New CMCF-ID IRELEC ISARA sample changer used for the first time...

Samples & Automounters

MxLIVE Update

Simple, secure & streamlined sample tracking and data management...

MxLIVE User Guide Page

1000 Structures & 500 Publications!

Celebrating two milestones reached by scientists who conducted their research at the CMCF

Full CLS News Story

Tackling Autoimmune Diseases

Researchers combine CMCF-BM, CMCF-ID, SAXS & electron microscopy data to discover B-cell CD22 interaction details critical to a healthy immune response...

Nature Commun. 8, 764


CMCF is an umbrella facility which operates two beamlines, 08ID-1 and 08B1-1, at the Canadian Light Source. Together, both beamlines enable high-resolution structural studies of proteins, nucleic acids and other macromolecules, satisfying the requirements of the most challenging and diverse crystallographic experiments.


  • Beamline 08ID-1 Status:  Normal Operations
  • Beamline 08B1-1 Status:  Normal Operations

List of Publications »

  • Bonday, Zahid Q.; Cortez, Guillermo S.; Grogan, Michael J.; Antonysamy, Stephen; Weichert, Ken et al. (2018). LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferas .... ACS Medicinal Chemistry Letters . 10.1021/acsmedchemlett.8b00014. [PDB: 6ckc]
  • Bagal; Sharan K.; Omoto; Kiyoyuki; Blakemore et al. (2018). Discovery of Allosteric, Potent, Subtype Selective, and Peripherally R .... Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.8b00280. [PDB: 6d20]
  • Huang; Christine S.; Oberbeck; Nina; Hsiao et al. (2018). Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activ .... Structure 26(5) , 767-777.e5. 10.1016/j.str.2018.04.002. [PDB: 5wni]