DNA DAMAGE REPAIR
How cells overcome some of the toxic effects of benzopyrene...
July 27, 2018
Benzo[a]pyrene (BP) is a frequently-encountered carcinogen that generates a bulky DNA adduct. DNA polymerase kappa is the only known polymerase that can bypass the adduct accurately and protect cells from genotoxic effects. In this Mail-In project, the authors compare binding of normal DNA with BP-adducted DNA to unravel the unique mechanism for accurate replication. PDB ID 4U7C.Nucleic Acids Res. 44, 4957