How the immune system responds to bacterial infections...

July 27, 2018

LPS is a major bacterial component recognized by the immune system, eliciting an inflammatory response followed by a state of immune tolerance. Acyloxyacyl hydrolase detoxifies LPS to re-establish sensitivity for subsequent infections. The structures described in this work address the questions of LPS recognition and selectivity toward acyl chains. Here, human acyloxyacyl hydrolase is shown with myristic, lauric and palmitic acids hidden deep within a hydrophobic pocket. PDB ID 5W78.