Exploring macromolecular machines that may one day produce novel therapeutics...
Jan. 22, 2016
Nonribosomal peptide synthetases (NRPSs) are large, complex proteins responsible for the production of many common antibiotics critical for human health. Making use of the Canadian Macromolecular Crystallography Facility beamlines, researchers have gained a new depth of understanding of NRPSs. Crystal structures of several functional confirmations were determined, supplying critical information about these macromolecular machines. This is an important step if NRPSs are to be used in the production of novel therapeutics. PDB ID: 5es5Nature 529, 239-42